Characterization of Presynaptic Protein Nerve wracked

描述(由申请人提供)：在本建议书中，我计划调查 果蝇NMJ突触突触的形成和功能这个 突触前对突触分化的控制很差 明白了。这种分化的一个表现是形成了 突触回合。突触突触几乎存在于所有突触中，除了 这些精索静脉曲张的形成及其功能尚未得到 通过实验解决。果蝇新基因的初步数据 伤脑筋的研究表明，该基因特异性地控制着 在NMJ的比赛。我计划进一步确定这个基因的特征并利用这个 研究突触突触的形成和功能的试剂。

DESCRIPTION (provided by applicant): In this proposal I plan to investigate the formation and function of the synaptic bouton at the Drosophila NMJ. The control of the differentiation of the synapse presynaptically is poorly understood. One manifestation of this differentiation is the formation of the synaptic bouton. Synaptic boutons are found at nearly all synapses but the formation of these varicosities as well as their function has not been addressed experimentally. Preliminary data from the novel Drosophila gene nerve-wracked suggests that this gene specifically controls the formation of boutons at the NMJ. I plan to further characterize this gene and use this reagent to investigate the formation and function of synaptic boutons.