Intermountain Pediatric Heart Disease Research Center

描述(由申请人提供) 心脏病是导致儿童发病和死亡的主要原因。一个 研究中心网络，拥有足够的临床人口和 经过培训进行多中心试验的研究人员团队可以提供 标准化、盲目、高质量的研究，具有统计能力 改变心脏病儿童的管理方式。小学生--S 位于犹他州盐湖城的医疗中心是唯一有资格 作为这样一个网络中的研究中心参与。它的作用是 山间领先的心脏病儿童转诊医院 西。拟议的山间儿科心脏病的总体目标 研究中心将在前瞻性、随机性、多机构合作 提供可靠数据的试验，从而促进 儿科心脏病知识与循证儿科 医药。山间儿科心脏病的具体目标 研究中心有：提出科学合理、统计稳健的建议 可在儿科心脏病中实施的研究方案 临床研究网：招收符合条件的小学生？S 医疗中心；并收集完整的数据并随时传达结果 在儿科心脏病临床研究网络内 促进研究成果的快速传播。我们建议两个 儿科心脏病临床研究网络的临床研究。 方案1的总体目标是“阿昔单抗治疗儿童的疗效” 与冠状动脉大动脉瘤的疗效进行比较的是阿昔单抗 在常规治疗的基础上加用常规治疗，而不是单独使用传统治疗 溶解或预防血栓，促进大体重塑 被归因于川崎病的冠状动脉动脉瘤，总体目标是 方案2，“脱细胞人同种异体瓣膜制剂(低温瓣膜)” 标准深低温保存带瓣同种异体血管重建的对比研究 儿童，是决定其功能和长期耐久性的 脱细胞同种异体瓣膜制剂与目前状况的比较- ART深低温保存同种异体带瓣移植物。调查人员同意 热心参与并努力遵守任何选定的协议 由儿科心脏病临床研究网提供。申请人 组织，小儿科？S医学中心，同意每位患者 选定的研究方案的运营成本的总和 儿科心脏病临床研究网。

DESCRIPTION (provided by applicant) Heart disease is a leading cause of morbidity and mortality in children. A network of research centers with both a sufficient clinical population and team of researchers trained to conduct multi-center trials could provide standardized, blinded, quality research that has the statistical power to change the way children with heart disease are managed. Primary Children?s Medical Center, located in Salt Lake City, Utah, is uniquely qualified to participate as a research center within such a network. It serves as the leading referral hospital for children with heart disease in the Intermountain West. The overall goal of the proposed Intermountain Pediatric Heart Disease Research Center is to collaborate in prospective, randomized, multi-institutional trials that provide robust data leading to the advancement of knowledge regarding pediatric heart disease and evidence-based pediatric medicine. The specific aims of the Intermountain Pediatric Heart Disease Research Center are: to propose scientifically sound, statistically robust research protocols that can be performed within the Pediatric Heart Disease Clinical Research Network; to enroll eligible children at Primary Children?s Medical Center; and to collect complete data and readily communicate results within the Pediatric Heart Disease Clinical Research Network so as to facilitate the rapid dissemination of research findings. We propose two clinical studies for the Pediatric Heart Disease Clinical Research Network. The overall goal of protocol 1, "Efficacy of Abciximab in Treating Children with Large Coronary Aneurysms," is to compare the effectiveness of abciximab added to conventional therapy versus conventional treatment alone for dissolving or preventing thrombi and for facilitating remodeling in large coronary artery aneurysms attributed to Kawasaki disease, The overall goal of protocol 2, "Decellularized Human Allograft Valve Preparation (Cryovalve SGR) versus Standard Cryopreserved Valved Allografts for Vascular Reconstruction in Children," is to determine the function and long-term durability of decellularized human allograft valve preparation versus the current state-of-the- art cryopreserved valved allograft. The investigators agree to enthusiastically participate in and diligently adhere to any protocol selected by the Pediatric Heart Disease Clinical Research Network. The applicant organization, Primary Children?s Medical Center, agrees to the per patient capitation of operational costs for the study protocols selected by the Pediatric Heart Disease Clinical Research Network.