Physiologic Characterization of Occupational Asthma

描述：这个特别强调研究奖将提供一个机会 对于一位年轻的职业流行病学家来说，他将从常规的实地考察中解脱出来 负责发展自己在分子方面的前沿研究 呼气中的生物标志物，并获得培训和经验 现代纵向生物统计学方法在职业研究中的应用 呼吸系统流行病学。该项目将最大限度地利用大型和 资金充足，正在进行的职业性哮喘社区研究和 哈佛大学S学术环境的深度和广度。 职业性哮喘(OA)占#年哮喘的5%至36% 成人和职业暴露是导致以下人群发病率的主要因素 成年哮喘患者。早期发现和干预是治疗原发性AS的关键 以及骨性关节炎的二级预防。不幸的是，生理上的 OA的表现很难理解，也很容易测量，而且是非侵入性的 骨性关节炎的生物标志物是迫切需要的。当前基于呼气峰的方法 心流(PEF)日记依赖于努力和努力的质量 无法控制记录。该项目将通过以下方式解决这些紧迫需求 阐明四种与工作相关的哮喘气流的关系 Sherwood Burge为PEF日记描述的模式(WRAAP)和观察到的WRAAP 使用便携式电子肺活量计，以及更复杂的生理和 呼吸道炎症的非侵入性生物标志物。这项研究将为 为这些新方法不仅在未来的职业中应用奠定了基础 流行病学研究，但也在工业筛查和门诊诊所。 因此，这项研究将照亮一条改进检测和预防的道路 骨关节炎。

DESCRIPTION: This Special Emphasis Research Award will provide an opportunity for a young occupational epidemiologist to be released from routine field study responsibilities to develop her own cutting edge research on molecular biomarkers in exhaled breath and to gain training and experience in the application of modern longitudinal biostatistical methods in occupational respiratory epidemiology. This project will take maximum advantage of large and well-funded ongoing community-based studies of occupational asthma and of the depth and breadth of Harvard?s academic environment. Occupational asthma (OA) accounts for 5 percent to 36 percent of asthma in adults and occupational exposure are major contributors to morbidity among adult asthmatics. Early detection and intervention are essential for primary as well as secondary prevention of OA. Unfortunately, the physiologic manifestations of OA are poorly understood and easily measured noninvasive biomarkers of OA are sorely needed. Current methods based on peak expiratory flow (PEF) diaries are effort dependent and the quality of the efforts and records cannot be controlled. This project will address these pressing needs by illuminating the relationship between the four work-related asthmatic airflow patterns (WRAAP) described by Sherwood Burge for PEF diaries and WRAAP observed using portable electronic spirometers, and a more sophisticated physiologic and noninvasive biomarker of airway inflammation. This study will lay the foundation for application of these new methods not only in future occupational epidemiologic studies, but also in industrial screening and outpatient clinics. Thus, this study will light a path toward improved detection and prevention of OA.