SUBSTANCE USE: FAMILY, FRIEND, AND COMMUNITY FACTORS

描述：（申请人摘要） 本申请K02奖的具体目的是促进 申请人的定量技能，这反过来又将使她能够建立在 她已经拥有的定性和定量技能，以及在很大程度上 她对药物滥用领域做出了质的贡献。大部分 她在药物滥用领域的工作是定性的， 仅限于不太先进的定量方法。最终，候选人 预计，先进的定性和 量化技能将使她能够继续做出贡献， 领域在研究计划中，申请人建议在她正在进行的研究的基础上， 关于母女之间代际药物滥用的研究。 虽然关于家庭、朋友和社区因素对药物滥用的研究 存在，许多问题仍然存在，关于风险之间的复杂关系， 和保护性因素。在拟议的研究中， 候选人的目标是：（1）确定物质使用，滥用 可卡因依赖青年（18 - 25岁）、他们的父母 和他们的兄弟姐妹这包括特定家庭成员的作用， 聚集，特定药物的家庭使用模式，以及 家庭物质使用;（2）探讨可卡因与 依赖和共病精神病理学，特别是抑郁，焦虑， 反社会人格障碍和创伤后应激综合征;（3） 研究具体社区因素在实质性发展中的作用 使用、滥用和依赖。这些因素涉及当地毒品市场力量， 例如可卡因和其他毒品的供应、价格和纯度; 关于物质使用的社区规范以及其他相关社区规范 特征;（4）调查风险和保护的动态 个人、家庭和社区层面的因素。发展和 应用程序的培训部分包括高级课程 统计技术。这种进一步的培训将使申请人能够 继续利用她现有的专业知识， 通过增加定量方法，她在很大程度上对该领域的贡献 质量工作。从教学和行政部门要求的释放时间 责任将允许候选人提高她的研究生涯。

DESCRIPTION: (Applicant's Abstract) The specific aim of this application for a K02 award is to advance the applicant's quantitative skills, which in turn will allow her to build on the qualitative and quantitative skills she already has as well as on the largely qualitative contributions she has made to the substance abuse field. Much of her work in the substance abuse field has been qualitative in nature or been limited to less advanced quantitative approaches. Ultimately, the candidate anticipates that an extensive knowledge of advanced qualitative and quantitative skills will allow her to continue to make contributions to the field. In the research plan, the applicant proposes to build on her ongoing research on intergenerational substance abuse among mothers and daughters. Although research on familial, friend, and community factors on substance abuse exists, many questions remain regarding the complex relationship between risk and protective factors at all three of these levels. In the proposed research, the candidate aims: (1) to determine familial patterns of substance use, abuse and dependence among cocaine-dependent young adults (ages 18-25), their parents and their siblings. This includes the role of specific family members, familial aggregation, familial use patterns of specific drugs, and the development of familial substance use; (2) to explore the association between cocaine dependence and comorbid psychopathology, particularly depression, anxiety, antisocial personality disorder, and post-traumatic stress syndrome; (3) to examine the role of specific community factors in the development of substance use, abuse, and dependence. These factors involve local drug market forces, such as the availability, price and purity of cocaine and other drugs; community norms regarding substance use, and other relevant community characteristics; and (4) to investigate the dynamics of risk and protective factors at the individual, familial, and community levels. The development and training component of the application includes course work in advanced statistical techniques. This further training will allow the applicant to continue to build on her existing expertise and to continue to make contributions to the field by adding quantitative approaches to her largely qualitative work. The requested release time from teaching and administrative responsibilities will allow the candidate to enhance her research career.