New Enantioselective Transition-Metal-Catalysed Domino Reactions

本项目的目标是开发新的合成方法，以制备对映体富集形式的重要手性化学结构单元。我们将以多米诺骨牌反应为目标，这些反应导致在同一个整体过程中形成两个或更多个碳-碳键。这些反应将通过基于第一行过渡金属如锰、钴、镍或铜的手性金属络合物与手性配体结合来催化，以有望诱导高的非对映选择性和对映选择性。

The goal of this project is to develop new synthetic methodology to prepare important chiral chemical building blocks in enantioenriched form. We will target domino reactions which result in the formation of two or more carbon-carbon bonds in the same overall process. These reactions will be catalysed by chiral metal complexes based upon first-row transition metals such as manganese, cobalt, nickel, or copper in conjunction with chiral ligands, to hopefully induce high diastereo- and enantioselectivities.