SLEEP DEPRIVATION, EEG, & FUNCTIONAL MRI IN DEPRESSION

描述（改编自申请人的摘要）：这5年的目标 Cametlia Clark，M.D.的指导临床科学家发展奖是 发展候选人在功能磁共振成像方面的专业知识 (MRI)同时利用她以前在神经成像和睡眠研究方面的技能。 这一目标将通过精心设计的培训计划来实现 涉及教学课程和专家指导（在加州大学圣地亚哥分校内外）， 基础神经科学、结构MRI、功能MRI（fMRI）物理学、睡眠和 情感障碍研究、统计学以及强化教学 在功能磁共振成像研究中，采用了最先进的扫描仪， 脉冲序列（特别是灌注加权），以及第一个功能磁共振成像研究 利用睡眠剥夺（SD）研究正常人的认知功能 （最近发表在Nature和NeuroReport上。该培训计划将 使克拉克博士能够完成向独立调查员的过渡， 为利用功能磁共振成像的长期研究计划提供基础， 多导睡眠描记法研究情感性精神障碍患者的脑功能。 该研究计划利用一个晚上的部分SD（PSD），一个很好的模型， 抗抑郁药治疗是速效的，不需要 药物治疗申请人假设：I）抑郁反应者的基线 腹侧前扣带回（BA 25和腹侧）灌注信号强度 24)/内侧前额叶皮质（BA 32）区域将大于 无应答者和对照组; 2）PSD后，腹前动脉灌注 扣带回（BA 25和腹侧24）/内侧前额叶皮质（BA 32和10） 只有应答者的面积会显著减少。申请人还将 在其他地区寻找组间和组内差异， 抑郁症的功能异常，包括（但不包括） 仅限于）背侧前扣带回，背外侧前额叶皮质，内侧 额叶皮质、杏仁核、海马体、丘脑和基底神经节。最后， 申请人将寻找可能的组间结构MRJ 这些差异可能会混淆fMRI分析。功能磁共振灌注成像 数据将通过AFNI中的方差分析算法进行分析（分析 功能性神经图像）软件。

DESCRIPTION (Adapted from applicant's abstract): The objective of this 5-year Mentored Clinical Scientist Development Award for Cametlia Clark, M.D. is to develop the candidate's expertise in functional magnetic resonance imaging (MRI) while building on her previous skills in neuroimaging and sleep research. This goal will be accomplished through a carefully designed training plan involving didactic courses and mentorship by experts (at and outside UCSD) in basic neuroscience, structural MRI, functional MRI (fMRI) physics, sleep and affective disorders research, and statistics as well as intensive instruction in fMRI research in a setting featuring state-of-the-art scanners, innovative pulse sequences (particularly perfusion-weighted), and the first fMRI studies utilizing sleep deprivation (SD) to study cognitive function in normal subjects (published recently in Nature and NeuroReport. This training program will enable Dr. Clark to complete the transition to independent investigator and provide the foundation for a long-term research program utilizing fMRI and polysomnography to investigate brain function in affective disorders. The research plan utilizes one night of partial SD (PSD), an excellent model of antidepressant treatment which is fast-acting, and does not require medications. The applicants hypothesize: I) depressed responders' baseline perfusion signal intensity in the ventral anterior cingulate (BA 25 and ventral 24) / medial prefrontal cortical (BA 32) areas will be greater than that of nonresponders and controls; 2) following PSD, perfusion in the ventral anterior cingulate (BA 25 and ventral 24) / medial prefrontal cortical (BA 32 and 10) areas will significantly decrease in responders only. The applicants will also look for between-groups and within-groups differences in other regions where functional abnormalities have been reported in depression, including (but not limited to) dorsal anterior cingulate, dorsolateral prefrontal cortices, medial frontal cortices, amygdala, hippocampus, thalamus, and basal ganglia. Finally, the applicants will look for possible between-groups structural MRJ differences, which could potentially confound fMRI analyses. FMRI perfusion data will be analyzed by the analysis of variance algorithm in AFNI (Analysis of Functional Neural Images) software.