Potentiation and repurposing of macrolide antimicrobials against Gram-negative pathogens for clinical applications in human and veterinary medicine

开发改进的抗菌策略是一项重要的全球性挑战。这个项目的目的是增强非关键大环内酯类抗生素的活性，使它们可以在人类和兽药的临床使用中取代关键抗生素的使用，例如粘菌素。这一目标将通过大环内酯类抗生素与肽模拟物（肽模拟物）和抗菌聚合物的络合和偶联来实现，建立在我们实验室强有力的体外证据基础上。抗菌、免疫调节和微生物组效应将在体外和体内进行测试，并使用细胞系统和猪和/或家禽模型。

The development of improved antibacterial strategies is an important global challenge. This project aims to potentiate the activity of non-critical macrolide antibiotics to the degree that they can be used to replace the use of critical antibiotics in clinical use in human and veterinary medicine, e.g., colistin. This aim will be achieved by complexing and conjugating macrolide antibiotics with peptide mimics (peptidomimetics) and antimicrobial polymers, building on strong in vitro evidence in our laboratories. The antibacterial, immunomodulatory and microbiome effects will be tested in vitro and in vivo, and by using cell systems and porcine and/or avian models.