To divide or to respond: the balanced matter of finding the right partner to coordinate morphological plasticity in plants

器官发育和生理的协调是植物生存的基础。植物器官的形态和功能依赖于细胞分裂的控制。因此，细胞周期的调节者，如细胞周期蛋白基因，往往是器官发育和环境线索的关键决定因素调节的目标。在植物中，细胞周期蛋白(Cyclin)的P型家族成员通过调节特定环境中的发育和生物功能，控制器官发育和生理协调。该研究项目将测试，在拟南芥中，环状蛋白是否在蛋白质-蛋白质水平上与器官模式的关键调节因子在不同的细胞和生理环境中动态相互作用，激活和停用它们的功能。在包括植物对磷(P)饥饿的反应在内的生理反应中，这些CyCPs/关键调控因子的相互作用具有调节形态适应和可塑性的潜力。磷的有效性是植物发育和生产力的一个主要限制因素，因此，解开支撑其严格调控的分子机制将允许战略性地改良农艺性状。为此，开展环氧氯丙烷在不同植物物种器官发育和生理反应中的作用研究(利用多态地钱草和辣椒)，将产生旨在提高作物产量的翻译方法，如油菜。这个项目将调查一个开创性的假设，即以CyCP为中心的模块代表了器官构型和生理协调的专用通用机制，这是细胞周期规范调控之外的细胞周期基因前所未有的角色。

Coordination of organ development and physiology is fundamental for plant survival. Plant organ patterning and function depends on the control of cell division. Hence, regulators of the cell-cycle such as cyclin genes are often targets of regulation by key determinants of organ development and environmental cues. It is hypothesised that in plants, members of the P-type family of cyclin (CYCPs) preside over the coordination of organ development and physiology, via regulating development and biological functions in specific contexts. The research project will test whether, in Arabidopsis thaliana, CYCPs dynamically interact at a protein-protein level with key regulators of organ patterning in distinctive cellular and physiological contexts, activating and deactivating their functions. These CYCPs/key-regulator interactions hold the potential to regulate morphological adaptation and plasticity during physiological responses, including the response of plants to phosphate (P)starvation. P availability is a major limiting factor for plant development and productivity, thus unlocking the molecular mechanism that underpins its tight regulation will allow strategic improvement of agronomic traits. For this purpose, carrying out the investigation of CYCPs' roles during organ development and physiological response across plant species (using Marchantia polymorpha and Capsella rubella), will generate translational approaches aimed to improve the yield in crops, like oilseed rape. This project will investigate a pioneering hypothesis that a CYCP-centric module represents a dedicated general mechanism for coordination of organ patterning and physiology, an unprecedented role for cyclin genes that lies beyond the canonical regulation of the cell-cycle.