New Directions in Cooperative Catalysis

协同催化是指多个分子位点协同作用来激活和转化小分子，这是一个越来越受关注的领域。我们之前已经探索了所谓的“受挫”路易斯对，其中酸性或碱性功能都是基于过渡金属配合物。该项目将以这些结果为基础，利用新的配体-金属组合赋予更高的官能团耐受性和潜在的手性。中间过渡金属将是一个焦点，因为它们在其他转变中具有良好的记录，这些特征很重要。我们将研究这些系统在小分子活化中的基本有机金属化学，特别是动态行为，以及催化作用。

Cooperative catalysis, in which multiple molecule sites act in concert to activate and transform small molecules, is a growing area of interest. We have previously explored so-called 'frustrated' Lewis pairs in which either the acidic or basic function is based on a transition metal complex. This project will build on these results using new ligand-metal combinations to impart higher functional group tolerance and potentially chirality. Mid-transitional metals will be a focus, since these have a good track record of other transformations in which these characteristics are important. We will study both the fundamental organometallic chemistry of such systems in small molecule activation, especially dynamic behaviour, as well as catalysis.