TOTAL SYNTHESIS OF POLYCYCLIC NATURAL PRODUCTS

描述：（主要研究者的摘要）虽然化学家已经成为 我们非常擅长构建少量非常复杂的分子， 通常不能以有效的， 实用和成本效益的方式。我们一般无法怀孕， 进行实际的实验室合成是我们科学的一个弱点。它 这项研究的长期目标是通过探索 实验室合成复杂有机结构的新策略。的 要合成的化合物是天然分子-生物碱，碳水化合物， 类异戊二烯和乙酸原。其目的不仅仅是制造化合物， 以一种能教会我们建筑方面新东西的方式来做 分子的构建。具体的合成目标是柱酰胺，discorhabdin D，sarain A，croomine，cephalostatin 12，euthyroideones A-C，arnoamines A-B， 盐氯、羽叶酸和牛磺羽叶酸。 这类研究的根本意义在于， 这个项目是提高我们的综合能力。正是由于这个原因 我们发现新的有机结构，并努力发现不明显的， 有效的方法来从商业上可获得的构建块组装它们。 我们作为合成化学家的最终目标是能够合成任何想要的 有机分子，无论多么复杂，以一种可以理解的方式， 商业生产。然而，我们选择的许多目标都有 内在的生物学重要性，我们的合成研究可能已经 直接的实际意义。这些靶点包括discorhabdin D， 头孢菌素12和卤氯，化合物如此罕见， 材料可用于全面的体内评价。通过全 我们希望综合解决这个问题。

DESCRIPTION: (Principal Investigator's Abstract) Although chemists have become rather adept at constructing small amounts of very complicated molecules, we generally cannot prepare most desired organic compounds in an efficient , practical, and cost-effective manner. Our general inability to conceive and execute practical laboratory syntheses constitutes a frailty of our science. It is the long-term goal of this research to address this deficiency by exploring new strategies for the laboratory synthesis of complex organic structures. The compounds to be synthesized are molecules of Nature-alkaloids, carbohydrates, isoprenoids, and acetogenins. The intent is not just to make compounds, but to do it in a way that will teach us something new about the architectural aspect of molecule-building. Specific synthetic targets are cylindramide, discorhabdin D, sarain A, croomine, cephalostatin 12, euthyroideones A-C, arnoamines A-B, halichlorine, pinnaic acid, and tauropinnaic acid. The fundamental significance of the kind of research being carried out in this project is the improvement of our synthetic abilities. It is for this reason that we identify novel organic structures and strive to discover non-obvious, efficient methods to assemble them from commercially-available building blocks. Our ultimate goal as synthetic chemists is to be able to synthesize any desired organic molecule, no matter how complex, in a manner that would be ameanable to commercial production. However, many of the targets we have chosen have intrinsic biological importance, and our synthetic research might have immediate practical importance. Among these targets are discorhabdin D, cephalostatin 12, and halichlorine, compounds so rare that insufficient material is available for full scale in vivo evaluation. Through total synthesis we hope to remedy this problem.