IL microemulsion extractions

背景提取是制药生产中的关键纯化工具，但大多是在批处理操作中完成的。在形成不想要的乳液/相以及提取亲水物种时会出现问题。这项研究发展了强化/连续萃取技术的化学和工程。除了传统的溶剂，疏水离子液体体系(IL)和基于离子液体的微乳液将与强化的液体提取技术相结合，以开发高效的连续健康工艺。这项工作的目标是快速、灵活、低成本、可靠和符合GMP的药品制造技术。EPSRC的研究领域包括：1)制造技术，2)工艺系统-部件和集成。大多数制药生产工艺不仅在传统上而且最近都是专门在批处理操作中完成的。现代制药生产组织希望提取过程能够与连续的上游流动合成和下游分离过程相结合。此外，与批量生产相比，连续生产提供了一系列适应优势，包括速度、规模最小化、灵活性和安全性，这使得过渡早该进行了。小型两相接触器的应用可以实现连续萃取。尺寸的减小带来了强化的优势，包括增加了传质，最大限度地减少了危险物质，改善了流体动力学控制，由于设备尺寸较小，降低了运营成本和资本成本。伦敦大学学院的泰晤士多相组开发了连续/强化溶剂萃取系统，包括撞击射流和小通道，具有高传质和减少溶剂使用量的特点，过去曾成功地用于金属萃取。在制药过程中，以目标产品的纯化和回收为目标的下游加工相关的高成本是限制许多生物基产品广泛使用的主要问题之一。分离过程和提纯阶段通常需要许多步骤，与高能源和化学品消耗相关，并占最终产品成本的很大比例。选择性不足是一个重大问题。在一步生产过程中，这会导致很高的产品损失。工艺助剂的加入增加了杂质的数量。从医学的角度来看，溶剂应该尽可能无害--这一事实极大地限制了试剂的选择。离子液体的使用可以解决这个问题。离子液体具有很高的溶剂化能力，有可能成为传统有机溶剂的绿色替代品。它们具有显著的物理化学性质，如低挥发性、高热稳定性和化学稳定性、低易燃性。目的：本项目的目的是开发和开发基于ILS的连续强化提取“疏水”微乳，并研究其在高效药物溶剂提取过程中的应用。博士研究计划如下所示。背景提取是制药生产中的关键纯化工具，但大多是在批处理操作中完成的。在形成不想要的乳液/相以及提取亲水物种时会出现问题。这项研究发展了强化/连续萃取技术的化学和工程。除了传统的溶剂，疏水离子液体体系(IL)和基于离子液体的微乳液将与强化的液体提取技术相结合，以开发高效的连续健康工艺。这项工作的目标是快速、灵活、低成本、可靠和符合GMP的药品制造技术。EPSRC的研究领域包括：1)制造技术

BackgroundExtraction is a key purification tool in pharmaceutical manufacturing but is mostly done in batch operations. Problems occur with the formation of undesirable emulsions/phases and when extracting hydrophilic species. This research develops the chemistry and engineering of intensified/continuous extraction technology. Apart from traditional solvents, water-hydrophobic ionic liquid systems (IL) and ionic liquid based microemulsions will be used together with the intensified liquid extraction techniques to develop efficient continuous processes for Health. The work targets fast, flexible, low cost, reliable, and GMP-compliant pharmaceutical manufacturing technologies. EPSRC Research Areas addressed are: 1) Manufacturing Technologies, 2) Process systems - components and integration.The majority of Pharmaceutical manufacturing processes have been not only traditionally but also recently done exclusively in batch operation. Modern pharmaceutical manufacturing organizations would like extraction processes that can integrate with continuous up stream flow synthesis and downstream isolation procedures. In addition, continuous manufacturing offers a range of advantages for adaptation over batch including speed, scale minimization, flexibility and safety, making the transition long overdue. Continuous extraction can be achieved by the application of small scale, two-phase contactors. The reduction in size leads to intensification with advantages including increased mass transfer, minimisation of hazardous materials, improved control of hydrodynamics, reduced operating cost and capital cost due to the smaller size of equipment. The ThAMes multiphase group at UCL has developed continuous/ intensified solvent extraction systems including impinging jets and small channels that show high mass transfer and reduced solvent use and have been successfully employed in the past for metal extractions.In pharmaceutical processes the high cost associated with downstream processing aimed at the purification and recovery of target products is one of the major issues limiting the widespread use of many bio-base products. Separation processes and purification stages usually require numerous steps associated with high energy and chemicals consumption and represent a large percentage of the cost of the final product. Insufficient selectivity is a significant issue. In an one-step process this results in high product losses. The addition of a process auxiliary increases the number of impurities. The solvent should from a medicinal standpoint be as harmless as possible- a fact that dramatically limits the choice of agents. The use of ionic liquids can address this issue. Ionic liquids have high solvation capabilities and the potential to be green alternatives to conventional organic solvents. They have remarkable physicochemical properties such as low volatility, high thermal and chemical stability, low flammability. Aim-Objectives The aim of the project is to develop and exploit continuous intensified extractions of 'hydrophobic water' microemulsions based on ILs and to study their application in efficient pharmaceutical solvent extraction processes. The plan for the PhD research is shown below. BackgroundExtraction is a key purification tool in pharmaceutical manufacturing but is mostly done in batch operations. Problems occur with the formation of undesirable emulsions/phases and when extracting hydrophilic species. This research develops the chemistry and engineering of intensified/continuous extraction technology. Apart from traditional solvents, water-hydrophobic ionic liquid systems (IL) and ionic liquid based microemulsions will be used together with the intensified liquid extraction techniques to develop efficient continuous processes for Health. The work targets fast, flexible, low cost, reliable, and GMP-compliant pharmaceutical manufacturing technologies. EPSRC Research Areas addressed are: 1) Manufacturing Tech