ROCHESTER EPIDEMIOLOGY PROJECT

罗切斯特流行病学项目（REP）是一个医疗记录 需要监测向居民提供的护理的联系系统 来自明尼苏达州的罗切斯特和奥姆斯特德县这种独特的基于人口的数据 基础设施提供详细的住院和门诊医疗服务， 向当地居民提供保健服务的提供者的记录。的信息 包含在这些记录中的是数百个 流行病学研究，提供了深入了解的频率，病因， 心脏病、中风、痴呆、帕金森病的自然病史和结局 疾病，癌症，糖尿病，消化系统疾病，骨质疏松症，关节炎和 许多其他的疾病。此外，该基础设施允许 进行这些研究的费用是2010年实现的费用的一小部分， 它的缺席。由于基础设施最初是为整个 在1966年的人口，1198出版物已产生，其中378在 最近4年。尽管马约诊所支持将诊断编入索引， 和程序在自己的记录，没有费用，这个项目，正在进行中 需要校外支持来收集诊断和程序信息 并将这些信息整合到患者身上， 水平正是基础设施的这一部分使REP成为 人口资源。具体而言，需要继续提供资金，用于： 通过继续识别个人来维持现有的基础设施 在当地医疗服务提供者的记录中，继续收集医疗信息， 来自非梅奥医疗服务提供者的奥姆斯特德县居民的事件数据， 继续将有关医疗保健的信息纳入相关的 （2）加强基础设施，以进行遗传学研究; 通过收集家族史和家族史信息进行流行病学研究 当地居民的结构，制定生物标本清单 从奥姆斯特德县居民和收集信息的风险 行为，体征和症状; 3）加强逻辑和分析 一般支持罗切斯特流行病学项目研究。这些活动 对于继续支持大规模流行病学研究是必不可少的。 由马约的研究人员在这一人群中进行的研究 全国各地的诊所和其他中心，包括30项独立研究 由美国国立卫生研究院在前一个赠款期资助。 虽然基础数据系统运行良好，但这些目标将使 申请人扩大这一研究基础设施的能力， 确保其未来的实用性。

The Rochester Epidemiology Project (REP) is a medical records linkage system that entails surveillance of the care delivered to the residents of Rochester and Olmsted County, Minnesota. This unique population-based data infrastructure provides access to the detailed inpatient and outpatient medical records of the providers of health care to local residents. The information contained in these records represents the foundation for hundreds of epidemiologic studies that provide insight into the frequency, etiology, natural history and outcomes of heart disease, stroke, dementia, Parkinson's disease, cancer, diabetes, digestive disorders, osteoporosis, arthritis and many other diseases in the population. Moreover, this infrastructure allows the conduct of these studies at a fraction of the cost that would be realized in its absence. Since the infrastructure was first organized for the entire population in 1966, 1198 publications have been generated, including 378 in the most recent 4 years. Although Mayo Clinic supports the indexing of diagnoses and procedures in its own records at no cost to this project, ongoing extramural support is needed to collect information on diagnoses and procedures from the non-Mayo providers and to integrate this information at the patient level. It is this portion of the infrastructure that makes the REP a population-based resource. Specifically, continued funding is needed for 1) maintaining the current infrastructure by continuing to identify individuals across the records of local providers of care, continuing to collect medical event data on Olmstead County residents from the non-Mayo providers of care and continuing the accession of information about medical care to the relational database; 2) enhancing the infrastructure for the conduct of genetic epidemiologic studies by collecting information on family history and family structure of local residents, developing an inventory of biological specimens collected from Olmsted County residents and collecting information on risk behaviors, signs and symptoms; and 3) enhancing the logistic and analytic support for Rochester Epidemiology Project studies generally. These activities are indispensable to the continued support of the large body of epidemiologic research that is being conducted in this population by investigators from Mayo Clinic and other centers throughout the country, including 30 separate studies funded by the National Institutes of Health through the previous grant period. Although the basic data system has worked well, these aims will allow the applicants to extend the capabilities of this research infrastructure and insure its future usefulness.