CENTER FOR CHILD ENVIRONMENTAL HEALTH RISKS RESEARCH

这项中心资助的主题是生化、分子和暴露。 定义儿童对杀虫剂敏感性的机制： 评估农药对正常发育和发展的影响 学习。与RFA的目标一致，我们设计了一个 多学科研究中心，利用 在华盛顿大学建立了风险研究的格局。我们 包括来自多个机构、学校和各种不同机构的成员 部门和诊所促进基础研究和应用研究 减少环境农药暴露的不利影响。至 对社区产生切实的影响，我们与 亚基马山谷农业中心内的华盛顿东部社区 共同完成国家对农药的干预和减少 儿童时期接触杀虫剂。我们设计了两个基于 研究项目和两个实地项目，其中包括一次曝光 路径研究项目加上相关领域的干预研究。 基于实验室的研究项目的具体目标将是 1)确定细胞、生化和分子机制 农药的不良发育神经毒性和2)鉴定 对氧磷酶基因多态性对发育的影响 有机磷农药的神经毒性。的具体目标 这两个基于现场的项目是：1)确定 2)对儿童进行干预以减少儿童的 接触杀虫剂。我们的四个设施核心(神经行为 评估、暴露评估、风险表征和风险 通信)旨在支持这一研究议程，并 把我们的研究放在儿童特有的风险评估背景下。因此，我们的 关于农药毒性和暴露的科学发现可以直接 纳入我们为保护儿童而设计的风险评估模型中 健康。

The theme of this center grant is the biochemical, molecular and exposure mechanisms that define children's susceptibility to pesticides: implications for assessing pesticide risks to normal development and learning. Consistent with the objectives of the RFA, we have designed a multi-disciplinary research center that takes advantages of the established landscape of risk research at the University of Washington. We have included members from multiple institutions, schools, and varied departments and clinics to facilitate both basic and applied research on reducing the adverse effects of environmental pesticide exposures. To achieve tangible effects on the community, we have partnered with an eastern Washington community within the Yakima Valley agricultural center of our state to jointly accomplish pesticide intervention with reduced childhood pesticide exposures. We have designed two laboratory based research projects and two field based projects which include an exposure pathways research project plus the related field based intervention study. The specific objectives of the laboratory based research projects will be to 1) identify cellular, biochemical and molecular mechanisms for the adverse developmental neurotoxicity of pesticides and 2) to identify the impact of genetic polymorphisms for paraoxonase on the developmental neurotoxicity of organophosphate pesticides. The specific objectives of the two field based projects are to 1) identify critical pathways of pesticide exposure for children and 2) to intervene to reduce children's exposure to pesticides. Our four facility cores (Neurobehavioral Assessment, Exposure Assessment, Risk Characterization and Risk Communication) have been designed to support this research agenda and to put our research into a child specific risk assessment context. Thus our scientific findings on pesticide toxicity and exposure can be directly incorporated into the risk assessment models we design to protect child health.