Does NHANES underestimate true population-based exposures to pesticides? Exploring bias in NHANES human biomonitoring data.

NHANES 是否低估了基于人群的农药真实暴露量？

• 批准号: 10648836
• 负责人: Dana Boyd Barr
• 金额: $ 8.62万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10648836
• 关键词: Age; Area; Biological Markers; Biological Monitoring; Blood; Blood specimen; Centers for Disease Control and Prevention (U.S.); Chemical Exposure; Chemicals; Collection; Complex; Cross-Sectional Studies; Data; Data Collection; Eligibility Determination; Ethnic Origin; Evaluation; Exposure to; Future; General Population; Guidelines; Health; Herbicides; Household; Human; Ice; Individual; Insecticides; Interview; Laboratories; Location; Logistics; Measurement; National Health and Nutrition Examination Survey; Nutrition Assessment; Outcome; Pesticides; Plasma; Population; Probability Samples; Protocols documentation; Public Health; Publications; Race; Reaction; Reference Values; Reporting; Research; Research Design; Sampling; Schedule; Seasons; Serum; Site; Techniques; Training; US State; United States National Center for Health Statistics; Urine; Variant; Weather; data centers; design; environmental chemical exposure; field survey; health assessment; health data; medical examination; operation; population based; programs; response; sample collection; sex; urinary; weather patterns

SUMMARY/ABSTRACT Human biomonitoring (HBM) – the measurement of a chemical, its reaction product, or metabolite in biosamples – is an exposure assessment technique that is often considered the “gold standard” in exposure assessment. The US uses the National Health and Nutrition Examination Survey (NHANES) as a vehicle for sample collection for its national HBM program. NHANES data collection occurs in Mobile Examination Centers (MEC), large trailers containing a mobile laboratory. Scheduling site locations for data collection includes considerations such as seasonal weather patterns and difficulties with MEC unit transit. Because MEC units cannot easily traverse difficult roadways with snow and ice patching, logistics require that sampling in areas often hit with harsh winter weather occur during the warmer months (i.e., spring and summer) whereas more temperate locations can be sampled in cooler months (i.e., winter and autumn). Given this, NHANES data that may vary by season could be subject to both temporal and spatial bias. This potential bias could, in turn, lead to inaccurate interpretations of population exposure and health data. We will evaluate any bias in HBM data of seasonal chemicals from NHANES using two specific aims. 1) Conduct state-level and seasonal evaluations of distributions of seasonal and non-seasonal chemical urinary biomarkers in NHANES Cycles 1999-2016 using the NCHS Research Data Center allowing access to restricted geocodes and sampling dates. 2) Compare NHANES state-level urinary pesticide metabolite data to smaller-scale biomonitoring studies conducted in different US states during different seasons. This study could provide information that will enable CDC to reconsider their sampling logistics to better represent seasonal and regional variations or will enable us to quantify the extent to which NHANES underestimates US population exposures.

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