CORE--STATISTICS, METHODS, OUTCOMES AND COMPUTER CENTER

该核心为本提案的所有项目提供行政、生物统计、流行病学、卫生经济学、技术援助和计算机科学支持。它继续在ARAMIS计划的前25年有效地发挥作用，并为拟议和未来的工作建立一个平台。它执行SCANHAQ程序，为ARAMIS内部和外部的调查员和医生提供支持。该核心负责中央结果评估、数据质量控制和后续活动。它负责严格和及时的绩效评估，数据质量控制和后续活动。它有责任严格和及时地执行所有项目任务，并从1)开始到2)患者招募，3)通过健康评估问卷（HAQ）评估结果，4)数据质量控制，5)分析，6)手稿准备和7)出版监督每个项目。它开发并提供通用字典、工具和项目协议。在本核心中，代表ARAMIS对研究问题的发展进行了讨论，并详细说明了我们对问卷扫描、生物统计程序和卫生经济学分析的一般方法。

This Core provides administrative, biostatistical, epidemiologic, health economics, technical assistance, and computer science support to all projects of this proposal. It continues the functions it has served effectively over the first 25 years of the of the ARAMIS Program and builds a platform for proposed and future work. It executes the SCANHAQ program which provides support to investigators and physicians both internal and external to ARAMIS. This Core is responsible for central outcome assessment, data quality control and follow-up activities. It has responsibility for rigorous and timely performance assessment, data quality control and follow-up activities. It has responsibility for rigorous and timely performance of all Project tasks, and monitors each project from 1) inception through 2) patient recruitment, 3) outcome assessment by Health Assessment Questionnaire (HAQ), 4) data quality control, 5) analyses, 6) manuscript preparation, and 7) publication. It develops and provides the common dictionaries, instruments, and project protocols. In this Core, representing both ARAMIS to development of the research questions to be addressed, and specify our general approaches to questionnaire scanning, biostatistical procedures, and health economics analyses.