Brain Lateralization in Adolescent Psychosis

描述（由申请人提供）：我们要求5年的支持， 青少年精神病大脑偏侧化研究精神障碍 在科学上或临床上都没有得到很好的理解， 青少年精神病的病因、预后和最佳治疗仍然是 不确定青少年在生物学取向的 神经精神病学研究，特别是在最近开发的背景下， 功能性和结构性脑成像指标已经在我们的研究中显示出了希望， 提高对成人精神病的认识。我们建议进行一项正式的研究 青少年发病精神病实施某些新的非侵入性 这些指标显示出极大的希望，可以提高我们对 成年精神障碍患者的疾病过程，包括 脑磁图（MEG）功能测量和磁共振 MRI结构测量。在患有精神障碍的成年人中， 发表的MEG和磁源成像（MSI）测量异常 大脑的结构和功能偏侧化。这些发现似乎 在几个主要的精神病患者中， 神经精神疾病，有一些建议，具体的 异常偏侧化的模式可以将这些疾病与一种 另这种异常，如果出现在青少年早期发病， 未分化的精神病，可能有助于1）更早，更准确 诊断，2）改善发病时的治疗计划，3）更准确 估计疾病轨迹和预后，以及未来的家庭研究 大脑偏侧化的遗传学

DESCRIPTION (Provided by Applicant): We are requesting 5 years of support for a study of brain lateralization in adolescent psychosis. The psychotic disorders in adolescents are not well understood scientifically or clinically, and the etiology, prognosis, and optimal treatments for psychosis in adolescents remain uncertain. Adolescents are underrepresented in biologically oriented neuropsychiatric research, especially within the context of recently developed functional and structural brain imaging metrics that have shown promise in our improved understanding of psychoses in adults. We are proposing a formal study of adolescent onset psychoses implementing certain of the new non-invasive metrics that have shown significant promise to improve our understanding of disease process in adults with psychotic disorders, including magnetoencephalography (MEG) functional measures, and magnetic resonance imaging (MRI) structural measures. in adults with psychotic disorders, we have published MEG and magnetic source imaging (MSI) measures of anomalous structural and functional lateralization of the brain. These findings appear to vary with the presence or absence of psychosis across several major neuropsychiatric disorders, and there is some suggestion that the specific patterns of anomalous lateralization may differentiate these disorders from one another. Such abnormalities, if present in adolescents with early onset, undifferentiated psychosis, may contribute to 1 ) earlier and more accurate diagnosis, 2) improved treatment planning at onset of illness, 3) more accurate estimate of illness trajectory and prognosis, as well as future family studies of the genetics of brain lateralization.