New Technologies in Electrophysiology Intervention

描述(由申请人提供)： Halperin博士的研究生涯的重点一直是扩展基础和 将调查应用于以患者为中心的研究。他的工作一直是 主要是在心肺复苏和 电生理学，他继续在那里应用基于科学的技术 向临床医学发展。他首先研究了 心肺复苏期间血液流动。这项工作导致了 提供高周向力的气动背心心肺复苏的研制 胸部按压。在临床前研究表明气动背心心肺复苏后 与人工心肺复苏术相比，改善了血流量和存活率，Dr。 Halperin开发了临床气动背心CPR系统，开发了协议 对于临床研究，获得FDA对临床研究的批准，以及 研究结果发表在《新英格兰医学杂志》上。 哈尔佩林博士的兴趣从心肺复苏扩大到 包括电生理学，因为引起心脏疾病的心律失常 逮捕是电生理学家的一个主要兴趣。一个主要的限制是 然而，研究患者的心律失常是缺乏能力的 精确关联解剖学和电学信息的技术。 解剖学源于x射线图像，它是二维的，具有 大量的解剖学上的歧义。另一个主要限制是缺乏 导管消融术中显示心肌消融面积的能力 程序。Halperin博士发明了将解剖学 来自磁共振成像(MRI)的信息，以及电生理 测试和导管消融。在临床前研究表明 磁共振引导下电生理检查和导管的可行性 消融，Halperin博士正在将这项技术扩展到以患者为导向 研究。哈尔佩林博士荣获生物工程研究伙伴奖 从NHLBI获得的拨款来实施这个项目，这是他目前的重点 研究。霍尔珀林？S博士继续应用科学依据 临床医学的技术发展表明了他以病人为本的承诺 以及他进行这项研究的能力。所有技术 已经足够发达，可以继续进行研究，但仍在继续 情况可能会有所改善。这项奖励将有助于腾出受保护的时间 进行这些原本会用于执行标准临床研究的研究 职责。通过提供50%的工资支持，这一奖励将允许至少50% 霍尔佩林医生被保护的时间不受标准病人护理活动的影响。 受保护的时间会让他有更多的时间追求以病人为中心 这项建议中概述的研究，并帮助培训年轻的临床 调查人员。

DESCRIPTION (provided by applicant): The focus of Dr. Halperin's research career has been extending basic and applied investigation to patient-oriented research. His work has been primarily in the fields of cardiopulmonary resuscitation and electrophysiology, where he continues to apply scientifically-based technology development to clinical medicine. He first studied the mechanisms whereby blood moved during cardiopulmonary resuscitation. That work led to the development of pneumatic vest CPR, which provides high-force circumferential chest compressions. After pre-clinical studies showed that pneumatic vest CPR improved blood flow and survival over that obtained with manual CPR, Dr. Halperin developed a clinical pneumatic vest CPR system, developed protocols for clinical studies, obtained FDA approval for the clinical studies, and published the results in the New England Journal of Medicine. Dr. Halperin's interests broadened from cardiopulmonary resuscitation to include electrophysiology, given that the arrhythmias that cause cardiac arrest are a major interest of electrophysiologists. A major limitation in studying arrhythmias in patients, however, is the lack of ability of current technology to accurately correlate anatomical and electrical information. Anatomy is derived from x-ray images, which are two-dimensional and have substantial anatomic ambiguity. Another major limitation is the lack of ability to visualize ablated areas of myocardium during catheter ablation procedures. Dr. Halperin has invented ways of combining the anatomic information from magnetic resonance imaging (MRI), with electrophysiologic testing and catheter ablation. After pre-clinical studies demonstrated the feasibility of performing MRI-guided electrophysiologic studies and catheter ablation, Dr. Halperin is extending this technology to patient-oriented research. Dr. Halperin has been awarded a Bioengineering Research Partnership grant from NHLBI to pursue this project, which is the current focus of his research. Dr. Halperin?s continued application of scientifically-based technology development to clinical medicine shows his commitment to patient-oriented research and his ability to perform that research. All technology has been sufficiently developed to allow the studies to proceed, but continued improvements will likely occur. This award would help free protected time to do these studies that would otherwise be used for performing standard clinical duties. By providing 50% salary support, this award would allow at least 50% of Dr. Halperin's time to be protected from standard patient care activities. That protected time would allow him more time to pursue the patient-oriented studies outlined in this proposal, and help train young clinical investigators.