SELECTIVE ESTROGEN RECEPTOR MODULATOR EFFECTS ON SEROTONIN GENE EXPRESSION
SELECTIVE ESTROGEN RECEPTOR MODULATOR EFFECTS ON SEROTONIN GENE EXPRESSION
批准号:
6592352
负责人:
CYNTHIA Louise BETHEA
金额:
$11.11万
依托单位国家:
美国
项目类别:
财政年份:
2002
资助国家:
美国
项目状态:
已结题
起止时间:
2002-05-01 至 2003-04-30
中文摘要
目前正在进行一项实验,以确定选择性雌激素是否
受体调节剂,称为雷洛昔芬和SERM 3,改变基因
在5-羟色胺神经元中以与自然相同的方式表达
雌激素。猴子被切除卵巢,然后用药物治疗一个月
赋形剂、雌激素、雷洛昔芬或SERM3,每天5毫克/公斤口服。之后
治疗后,对猴子实施安乐死,并获取中脑用于
5-羟色胺再摄取转运体基因表达的测定
和5HT1a自身受体基因。资助礼来制药公司。
出版物无
英文摘要
An experiment is underway to determine if the selective estrogen
receptor modulators, called raloxifen and SERM 3, alter gene
expression in serotonin neurons in the same manner as natural
estrogen. Monkeys are spayed and then treated for one month with
vehicle, estrogen, raloxifen, or SERM3 at 5 mg/kg/day orally. After
treatment, the monkeys are euthanized and the midbrain is obtained for
determination of expression of the serotonin reuptake transporter gene
and the 5HT1A autoreceptor gene. FUNDING Eli Lilly Pharmaceutical Co.
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Postmenopausal Monkey Resource
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批准号:9104295
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项目类别:
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资助金额:$25.63万
-
财政年份:2012
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负责人:CYNTHIA Louise BETHEA
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依托单位:
Postmenopausal Monkey Resource
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批准号:8337472
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项目类别:
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资助金额:$84.76万
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财政年份:2012
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负责人:CYNTHIA Louise BETHEA
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依托单位:
Postmenopausal Monkey Resource
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批准号:8705065
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项目类别:
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资助金额:$53.46万
-
财政年份:2012
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负责人:CYNTHIA Louise BETHEA
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依托单位:
Postmenopausal Monkey Resource
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批准号:8532068
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项目类别:
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资助金额:$48.85万
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财政年份:2012
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负责人:CYNTHIA Louise BETHEA
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依托单位:
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批准号:8357731
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资助金额:$5.82万
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负责人:CYNTHIA Louise BETHEA
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依托单位:
ROLE OF SEROTONIN IN MEDIATING STRESS-INDUCED INFERTILITY
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批准号:8357841
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项目类别:
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资助金额:$5.82万
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财政年份:2011
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负责人:CYNTHIA Louise BETHEA
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依托单位:
OVARIAN STEROID REGULATION OF SEROTONIN NEURAL FUNCTION
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批准号:8357840
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项目类别:
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资助金额:$5.82万
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财政年份:2011
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负责人:CYNTHIA Louise BETHEA
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依托单位:
IN VITRO MODEL DEVELOPMENT OF SEROTONIN NEURONS
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批准号:8357741
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项目类别:
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资助金额:$3.63万
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财政年份:2011
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负责人:CYNTHIA Louise BETHEA
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依托单位:
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批准号:8357842
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项目类别:
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资助金额:$5.82万
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财政年份:2011
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负责人:CYNTHIA Louise BETHEA
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TISSUE BANK
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批准号:8125604
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项目类别:
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资助金额:$2.78万
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财政年份:2010
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负责人:CYNTHIA Louise BETHEA
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依托单位:
IN VITRO MODEL DEVELOPMENT OF SEROTONIN NEURONS
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批准号:8173186
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项目类别:
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资助金额:$4.76万
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财政年份:2010
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负责人:CYNTHIA Louise BETHEA
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依托单位:
Steroid Regulation of Serotonin in Males
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批准号:8241173
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项目类别:
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资助金额:$32.37万
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财政年份:2010
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负责人:CYNTHIA Louise BETHEA
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依托单位:
Steroid Regulation of Serotonin in Males
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批准号:8403735
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项目类别:
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资助金额:$30.96万
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财政年份:2010
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负责人:CYNTHIA Louise BETHEA
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依托单位:
Norepinephrine in Stress-Induced Amenorrhea of Macaques
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批准号:8116585
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项目类别:
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资助金额:$25.2万
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财政年份:2010
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负责人:CYNTHIA Louise BETHEA
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依托单位:
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批准号:8173177
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项目类别:
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资助金额:$7.61万
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财政年份:2010
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负责人:CYNTHIA Louise BETHEA
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依托单位:
Steroid Regulation of Serotonin in Males
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项目类别:
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资助金额:$49.71万
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财政年份:2010
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负责人:CYNTHIA Louise BETHEA
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依托单位:
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项目类别:
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资助金额:$32.14万
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财政年份:2010
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负责人:CYNTHIA Louise BETHEA
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依托单位:
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项目类别:
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资助金额:$21.78万
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财政年份:2010
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负责人:CYNTHIA Louise BETHEA
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依托单位:
Steroid Regulation of Serotonin in Males
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批准号:8079556
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项目类别:
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资助金额:$33.46万
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财政年份:2010
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负责人:CYNTHIA Louise BETHEA
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依托单位:
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项目类别:
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海外基金