CORE--BIOSTATISTICS

生物统计核心的主要目标是提供旧金山弗朗西斯科 治疗研究中心（TRC）支持所有定量和 真相与和解委员会研究的方法问题。第二个目标是进行原创 研究与这些问题直接相关的具体统计问题 问题研究本提案介绍了该核心的计划活动。核心 旨在实现以下具体目标：（1）提供 对每个组成部分进行方法咨询和生物统计分析;（2） 为收集提供结构、支持、协调和监督， 研究数据的计算机录入和管理;（3）确保研究数据的安全性， （4）进行一系列互相关连的研究 现有的方法，用于分析离散的结果，从纵向 在缺少数据的情况下进行研究。该核心将支持 四个拟议构成部分的生物统计和数据相关活动， 将在新的环境中研究复杂药物滥用患者的治疗方法。从 数据分析的角度所有组成部分的研究包括一些共同的 特点：一个比较组，招募和登记参与者 顺序地，包括连续和离散的多个测量 结果，参与者在一段时间内重复测量， 多个假设和参与者流失。每个组件还将 提出了独特的分析挑战。此核心将执行数据输入和数据 管理，该核心还将维护中心的计算机系统。一个 计划的生物统计核心活动的一个组成部分是一个计划， 研究的重点是真理与和解委员会面临的一个重要的方法问题 组成项目：选择数据分析的最佳统计检验 使用离散结果的纵向研究。基于当前 将使用研究、计算机模拟和真实的数据来研究这些影响 样本量，流失率和模式，以及缺失的行为数据 统计模型。单个TRC的参数值和数据 将在这项研究中使用的组件，以便调查结果将直接 适用于这些项目的分析。

The primary goal of the Biostatistics core is to provide the San Francisco Treatment Research Center (TRC) with support for all of the quantitative and methodological aspects of TRC studies. A secondary goal is to conduct original research of specific statistical issues directly relevant to those same studies. This proposal describes the planned activities of this Core. The core is designed to accomplish the following specific aims: (1) to provide methodological consultation and biostatistical analyses for each component; (2) to provide structure, support, coordination and oversight for collection, computer entry, and management of research data; (3) to insure the security and integrity of all TRC data; and (4) to conduct a series of inter-related studies of existing methods for the analysis of discrete outcomes from longitudinal studies in the presence of missing data. This Core will support the biostatistical and data-related activities of the four proposed components that will study treatments for complex drug-abusing patients in new settings. From a data analysis perspective all component studies include a number of common features: a comparison group, recruiting and enrolling participants sequentially, multiple measures including both continuous and discrete outcomes, participants followed over a time course with repeated measurements, multiple hypotheses, and participant attrition. Each component will also present unique analytic challenges. This Core will perform data entry and data management, and this Core will also maintain the Center computer systems. An integral aspect of the planned Biostatistical Core activities is a program of research focused on an important methodological problem faced by the TRC component projects: choosing the best statistical test for the analysis of data from longitudinal studies using discrete outcomes. Building on current research, computer simulations and real data will be used to study the effects of sample sizes, attrition rates and patterns, and missing data on the behavior of statistical models. Parameter values and data from the individual TRC components will be used in this research so that findings will be directly applicable to the analysis of those projects.