COGENT TO SUPPORT CLINICAL RESEARCH AT STANFORD

描述(改编自申请者摘要)：这是一份申请 四年有力资金支持7名NIMH资助的R01‘S，由6名PI领导 斯坦福大学心理学的精神病学和行为科学系 大学。R01‘S关注的是一些疾病-严重的抑郁症 没有精神病特征的强迫症，创伤后 应激障碍、脆性X综合征和其他神经遗传综合征，以及精神分裂症。 这种说服力将提高每一项已获批准的研究的效率 这些研究，扩大了它们的范围，并允许进行重大的交叉研究 合作。它包括3个核心--征聘、统计和数据 管理和神经成像。招聘核心将设在三个地点 两个地点(两个在帕洛阿尔托，一个在旧金山)，以增加招聘 研究对象。旧金山的网站将提供更多的种族 基本补助金的少数族裔科目。核心将为科目提供便利 参与不止一项研究。统计和数据管理核心 将协助开发可跨研究使用的方法 纵向过程和结果(例如随机回归模型)、响应 随机临床试验(例如，接收器工作特性曲线 方法)，以及多种风险因素的相对贡献。这个 神经成像核心将提供研究前对模拟器的暴露，并提供 额外的扫描时间。这一令人信服的主要特征是功能磁共振成像的应用 在基础补助金中研究的不同人群中。其中的几个 已经有研究使用功能磁共振成像来研究特定疾病的情感和认知-- 例如，精神分裂症、非精神病性和精神病性抑郁症、社会性 恐惧症、脆性X等。有说服力的人将允许使用标准的功能磁共振成像 在这些患者组中进行的实验将允许进行比较 跨项目--例如，出现幻觉的精神分裂症患者 精神病抑郁症患者。在两项研究中，功能磁共振成像的使用将显著 通过探索治疗的具体效果来加强研究设计 大脑功能。

DESCRIPTION (Adapted from the Applicants Abstracts): This is an application for four years of CoGent funding to support 7 NIMH-funded R01's led by six PI's in the Departments of Psychiatry and Behavioral Sciences of Psychology at Stanford University. The R01's focus on a number of disorders - major depression with and without psychotic features, obsessive compulsive disorder, post-traumatic stress disorder, fragile X and other neurogenetic syndromes, and schizophrenia. This CoGent will increase the efficiency of the approved research of each of the studies, expand their scope, and allow for significant cross study collaborations. It consists of 3 cores - Recruitment, Statistics and Data Management, and Neuroimaging. The Recruitment Core will be located across three sites (two in Palo Alto and one in San Francisco) to increase recruitment of subjects. The San Francisco site will provide greater numbers of ethnic minority subjects for the Base Grants. The Core will facilitate subjects participating in more than one study. The Statistic and Data Management Core will assist in developing methods that can be used across studies for accessing longitudinal course and outcome (e.g. random regression models), response in randomized clinical trials (e.g. Reciever Operating Characteristics Curve Methodology), and the relative contributions of multiple risk factors. The Neuroimaging Core will offer prestudy exposure to a simulator and provide for additional scan time. A major feature of this CoGent is the application of fMRI across different populations being studied in the Base Grants. Several of the studies already use fMRI to study affect and cognition in specific disorders - e.g., schizophrenia, nonpsychotic and psychotic major depression, social phobia, fragile X, etc. The CoGent will permit utilization of standard fMRI experiments in these patient groups that will allow comparisons to be made across projects - e.g., hallucinating schizophrenic patients with hallucinating psychotic depressives. In two studies, the use of fMRI will significantly enhance the research design by exploring the specific effects of treatment on brain function.