DEVELOPMENTAL CEREBRAL BLOOD FLOW AND METABOLISM

描述(由申请人提供) 胎儿时期出现的脑血流和代谢障碍 新生儿期是永久性脑损伤的主要原因， 儿童和成人的大脑功能障碍。围产期脑的动物模型 损害已经存在了20多年，这有助于 阐明所涉及的生理和生化过程。更多 近年来，细胞和分子生物学技术已被应用于 脑发育正常和异常的研究。因此，总体上， 拟议会议的目标是将国际知名人士聚集在一起 参与脑血研究的临床和基础科学家 发育中的动物和人类的流动和新陈代谢。会议将集中讨论 主要探讨脑发育正常和异常的机制以及 功能，并将根据我们以前成功的会议进行风格化 1997年和2000年在宾夕法尼亚州好时举行。五大主题将是 内容包括：1)发育的细胞和分子生物学；2)缺氧-缺血； 3)癫痫、毒素、神经创伤和代谢性脑病；4) 神经保护和功能结局；5)发育的动物模型 脑部受伤。一个或多个平台和海报会议将专门针对每个 主题，预计所有与会者都将出席并参与 积极参与。几位受邀的演讲者已经承诺 会议，等待NIH的财政支持。会议的背景是在 宾夕法尼亚州的好时，将提供一种放松的乡村氛围，这种氛围仍然 所有主要城市都可以很方便地到达。预计这次会议将 将汇聚一批杰出的临床和基础科学家 促进最大限度的互动和传播的非正式环境 新的和令人兴奋的研究。

DESCRIPTION (provided by applicant) Disturbances in cerebral blood flow and metabolism occurring during the fetal and neonatal periods are major contributors to permanent brain damage and cerebral dysfunction in children and adults. Animal models of perinatal brain damage have been available for more than two decades, which have aided in the elucidation of the physiologic and biochemical processes involved. More recently, cellular and molecular biological techniques have been applied to the study of normal and abnormal cerebral development. Accordingly, the overall objective of the proposed meeting is to bring together internationally known clinical and basic scientists involved in research pertaining to cerebral blood flow and metabolism in developing animals and humans. The conference will focus primarily on mechanisms of normal and abnormal cerebral development and function and will be stylized according to our previously successful meetings held in Hershey, Pennsylvania, in 1997 and 2000. Five major themes will be covered: 1) Cellular and Molecular Biology of Development; 2) Hypoxia-Ischemia; 3) Epilepsy, Toxins, Neurotrauma, and Metabolic Encephalopathies; 4) Neuroprotection and Functional Outcome; and 5) Animal Models of Developmental Brain Injury. One or more platform and poster sessions will be devoted to each theme with the anticipation that all attendees will present and also engage in active participation. Several invited speakers are already committed to the conference, pending NIH financial support. The setting of the meeting in Hershey, Pennsylvania, will provide a relaxing, rural atmosphere which is still readily accessible to all major cities. It is anticipated that the conference will bring together an outstanding group of clinical and basic scientists in an informal environment to promote maximal interaction and the dissemination of new and exciting research.