AMBLYOPIA IN ASTIGMATIC CHILDREN-DEVELOPMENT & TREATMENT

描述：(申请人摘要)来自科学文献的证据 表明儿童时期未矫正的散光与 弱视的三种类型：(1)最佳矫正视力和 正交栅(子午线弱视或MA)的对比敏感度，(2) 正交化游标视力最佳矫正视力的差异 刺激(也称为MA)，以及(3)最佳校正识别缺陷 (字母)敏锐。这些数据表明，美国经济存在一段敏感期 散光相关性弱视的发展。然而，只有有限的信息 关于影响发展和治疗的因素是可用的 散光相关性弱视。 缺乏关于散光相关弱视的研究很可能是由于 由于散光在大多数儿童群体中的低流行率。然而， 大量散光和散光相关的高患病率 Tohono O‘Odham小学的学生中有弱视的记录 儿童目前没有戴眼镜矫正。这一点的存在 未经矫正的高度散光儿童的大样本提供了独特的 发展与治疗研究的契机 散光相关性弱视。 本研究的目标是：(1)确定视力缺陷的特征 与散光相关的弱视相关(通过测量光栅 敏感度、游标敏锐度、识别敏锐度和对比敏感度)，(2)至 确定散光相关性弱视发展的影响因素 (例如，散光量和类型等因素)，以及(3)确定 眼镜干预对散光相关性弱视的年龄特异性影响。 这项拟议的研究将提供有价值的关于 散光相关性弱视的发展和治疗。此外，它还 将为Tohono O‘Odham的成员提供有价值的公共卫生服务。

DESCRIPTION: (Applicant's Abstract) Evidence from the scientific literature indicates that uncorrected astigmatism during childhood is associated with three types of amblyopia: (1) a difference in best-corrected acuity and contrast sensitivity for orthogonal gratings (meridional amblyopia or MA), (2) a difference in best-corrected acuity for orthogonally-oriented vernier acuity stimuli (also termed MA), and (3) a deficit in best-corrected recognition (letter) acuity. These data suggest the presence of a sensitive period for the development of astigmatism-related amblyopia. However, only limited information is available concerning factors that influence the development and treatment of astigmatism-related amblyopia. The lack of research regarding astigmatism-related amblyopia is most likely due to the low prevalence of astigmatism in most populations of children. However, a high prevalence of large amounts of astigmatism and astigmatism-related amblyopia has been documented in members of the Tohono O'Odham grade-school children are not currently wearing eyeglass correction. The presence of this large sample of uncorrected highly astigmatic children provides a unique opportunity for the study of the development and treatment of astigmatism-related amblyopia. The goals of the present study are: (1) to characterize vision deficits associated with astigmatism-related amblyopia (through measurements of grating acuity, vernier acuity, recognition acuity, and contrast sensitivity), (2) to identify factors influencing the development of astigmatism-related amblyopia (e.g., factors such as amount and type of astigmatism), and (3) to determine age-specific effects of glasses intervention on astigmatism-related amblyopia. The proposed study will provide valuable clinical information regarding the development and treatment of astigmatism-related amblyopia. In addition, it will provide a valuable public health service to members of the Tohono O'Odham.