MULTIDISCIPLINARY TRAINING IN EXPERIMENTAL HEMATOLOGY

描述（申请人摘要）本申请请求支持建立一个新的血液病多学科研究培训计划。 血液疾病仍然是美国发病率和死亡率的主要来源。马约诊所有着培养学术血液学家的悠久传统。最近的分析表明，马约诊所血液学/肿瘤学临床奖学金计划的近一半毕业生在奖学金后有实验室研究承诺。 为了更好地装备这些学术医生，以及合适的博士学位。为了满足对血液病感兴趣的科学家对假设驱动的实验室研究的后续追求，我们设计了血液学研究培训计划。 培训教师由32名由壁外资助的研究人员组成，他们的实验室研究项目包括：1）骨髓和淋巴恶性肿瘤，2）细胞因子，3）凝血和微循环，4）分子治疗学，5）实验免疫学，6）临床和遗传流行病学。每个受训者将被要求在其中一个培训学院的实验室完成至少两年的假设驱动的研究。 这种实践研究经验将通过参加生物化学和分子生物学研讨会，血液学核心教学讲座和GCRC课程的“研究的实践方面”来补充。“此外，我们亦鼓励学员修读额外的生物化学、免疫学、分子生物学、生理学、分子药理学或肿瘤生物学课程，以扩展他们在研究项目相关范畴的知识基础。” 我们最初建议每年招募1-2名学员，稳定状态计划为3名学员。 该血液学研究培训计划将由Scott Kaufmann，M.D.共同指导，哲学博士、和Robert A.医学博士凯尔两人都是由壁外资助的研究人员，其项目重点是血液病。 该计划将由一个四人委员会管理，其中包括考夫曼博士和凯尔。 我们将寻找具有医学博士学位的合格候选人，哲学博士、或医学博士/博士背景 现已建立积极征聘合格的少数族裔和妇女候选人的机制。 该计划是现有血液学培训机会的自然产物，但将为血液病的实验室研究提供更好的准备。 (End摘要）

DESCRIPTION (Applicant's Abstract) This application requests support to establish a new multidisciplinary research training program in hematological diseases. Hematological diseases remain a major source of morbidity and mortality within the United States. The Mayo Clinic has a long tradition of training academic hematologists. Recent analysis indicates that approximately half of the recent graduates of the Mayo Clinic hematology/oncology clinical fellowship program have laboratory research commitments following fellowship. To better equip these academic physicians, as well as suitable Ph.D. scientists interested in hematological diseases, for subsequent pursuit of hypothesis-driven laboratory investigation, we have designed a Hematology Research Training Program. The training faculty consist of 32 extramurally funded investigators with laboratory research programs in 1) myeloid and lymphoid malignancies, 2) cytokines, 3) coagulation and microcirculation, 4) molecular therapeutics, 5) experimental immunology, and 6) clinical and genetic epidemiology. Each trainee will be expected to complete at least two years of hypothesis-driven research in the laboratory of one of these training faculty. This hands-on research experience will be supplemented by required attendance at Biochemistry & Molecular Biology seminars, Division of Hematology Core didactic lectures, and a GCRC course on "Practical Aspects of Research." In addition, trainees will be encouraged to take additional biochemistry, immunology, molecular biology, physiology molecular pharmacology or tumor biology courses as needed to extend their knowledge bases in areas related to their research projects. We initially propose to recruit 1-2 trainees per year, with a steady state program of three trainees. This Hematology Research Training Program will be co-Directed by Scott Kaufmann, M.D., Ph.D., and Robert A. Kyle, M.D., both of whom are extramurally funded investigators with programs focused on hematological diseases. The program will be administered by a four member committee that includes Drs. Kaufmann and Kyle. We will seek qualified candidates with M.D., Ph.D., or M.D./Ph.D. backgrounds. Mechanisms are in place for aggressive recruitment of qualified minority and women candidates. This program is a natural outgrowth of existing training opportunities in hematology, but will provide better preparation for laboratory research in hematological diseases. (End of Abstract)