TRAINING: HEMATOLOGY, IMMUNOLOYG & STEM CELL BIOLOGY

（摘自申请人摘要） 这是一个建立一个 分子与细胞跨学科博士后培养计划 生物学，重点是血液学，免疫学和干细胞生物学， 奥克兰儿童医院研究所（CHORI） 支持6 每年都有博士后申请。 受训人员， 哲学博士、医学博士/博士或者医学博士学位有资格参加该计划。 学员 预计在细胞或分子生物学方面有很强的背景， 遗传学，生物化学或生理学，以便被接受进入程序。 该计划强调在经验丰富的， NIH支持的研究者。 由CHORI的导师组成的委员会将 选择候选人，并将决定他们将在实验室 工作 每个学员将发展一个研究假设，并写一个迷你 该提案将由PI审查。和Co-PI。 学员将参加核心课程活动，并将在 每月讨论个别项目的进展情况并提交数据。 此外，受训人员将参加每周一次的实验室会议， 由他们的导师，每周杂志俱乐部指导的PI。和Co-PI和 在CHORI举办的每周研讨会系列。 学员将被要求 在全国会议上介绍他们的研究成果。 所有受训人员将被要求 准备一份研究计划书，在他们的第二次或第三次申请期间寻求校外资助。 第三年训练。 导师将协助准备此申请。 研究培训机会在这个计划将包括：1）学习如何 开展血液学临床研究，重点关注镰状细胞性贫血 2）红细胞膜结构和功能的研究 利用分子、生物化学和生物物理技术，3）研究 免疫发育，对肽模拟物的免疫应答，分子 分析HLA系统及其与免疫缺陷的关系 血红蛋白病患者，4）铁代谢和分子生物学研究 铁蛋白的调节，5）脂质介导的信号转导的研究， 细胞生物学，6）细胞遗传操作的研究，特别是 造血干细胞，使用腺相关病毒载体，和7）研究 造血干细胞生物学，重点是脐带血造血 干细胞 这一系列由NIH资助的研究， 博士学位将为学员提供丰富的经验，并将解决需要 对血液学研究特别感兴趣的年轻科学家， 适用于血红蛋白病领域。 1

(Adapted from applicant's abstract) This is a proposal to establish an interdisciplinary postdoctoral training program in molecular and cellular biology with a focus on hematology, immunology and stem cell biology at the Children's Hospital Oakland Research Institute (CHORI). Support for six postdoctoral fellows is requested in each year of this grant. Trainees with Ph.D., M.D./Ph.D. or M.D. degrees are eligible for the program. Trainees are expected to have a strong background in either cell or molecular biology, genetic, biochemistry or physiology in order to be accepted into the program. The program emphasis hands-on bench work in the laboratory of an experienced, NIH supported investigator. A committee composed of the mentors at CHORI will select the candidates and will determine the laboratory in which they will work. Each trainee will develop a research hypothesis and write a mini proposal which will be reviewed by the P.I. and Co-PI of this application. Trainees will participate in core curriculum activities and will meet on a monthly basis to discuss progress on individual projects and to present data. In addition, trainees will participate in weekly laboratory meetings directed by their mentors, weekly journal clubs directed by the P.I. and Co-P.I., and weekly seminar series conducted at CHORI. Trainees will be expected to present their research at national meetings. All trainees will be expected to prepare a research proposal seeking extramural funding during their second or third year of training. The mentor will assist in preparing this application. Research training opportunities in this program will include: 1) Learning how to conduct clinical research in hematology with a focus on sickle cell anemia and thalassemia, 2) Studying red cell membrane structure and function studies using molecular, biochemical and biophysical techniques, 3) studying immunologic development, immune response to peptide mimetics, molecular analysis of the HLA system and their relationship to immune defects in patients with hemoglobinopathies, 4) Studies in iron metabolism and molecular regulation of ferritin, 5) studies of lipid mediated signal transduction in cell biology, 6) studies of genetic manipulation of cells, particularly hematopoietic stem cells, using adeno-associated viral vectors, and 7) studies of hematopoietic stem cell biology, with a focus on cord blood hematopoietic stem cells. This spectrum of research conducted by NIH funded M.D.s and Ph.D.s will provide a rich experience for trainees and will address the need for young scientists with a particular interest in hematology research that applies to the field of hemoglobinopathies. 1