Late Effects of Cancer Treatment

对接受放射治疗和化疗的癌症长期幸存者的研究导致了对癌症发生的重要见解。与辐射流行病学分会合作，我们继续对患上黑色素瘤的视网膜母细胞瘤幸存者进行研究。视网膜母细胞瘤的治疗信息已经可用，我们最近获得了整个队列的阳光、烟草和酒精暴露信息。死亡率分析表明，遗传性视网膜母细胞瘤后肺癌明显过剩，而没有明显的过度吸烟。发病年龄比SEER报告的年龄更早，根据很少的数字，小细胞癌的比例不成比例。没有发现与辐射有关的因素。我们继续在儿童时期接受头部和颈部照射的一群人中进行与辐射相关的神经肿瘤的实地研究。我们计划为这项研究增加多达40名患有头颈部神经肿瘤的队列成员。基于文献综述，假设视网膜母细胞瘤、尤文肉瘤和鼻窦神经外胚层癌之间存在关联。

Studies of long-term survivors of cancer treated with radiation therapy and chemotherapy have led to important insights into carcinogenesis. In collaboration with the Radiation Epidemiology Branch, we have continued a study of survivors of retinoblastoma who have developed melanoma. Information on treatment for the retinoblastoma is already available, and we have recently obtained sun, tobacco, and alcohol exposure information for the entire cohort. Mortality analyses have indicated that there is a significant excess of lung cancer following heritable retinoblastoma, without any apparent excess smoking. The age of onset is younger than that reported in SEER, with a disproportionate percentage of small cell carcinoma, based on few numbers. No relationship with radiation was found. We have continued the field work for the study of radiation-related neural tumors in a cohort of individuals who received head and neck irradiation in childhood. We plan to add up to 40 additional cohort members to the study who have developed head and neck neural tumors. Based on a literature review, an association between retinoblastoma, Ewing sarcoma, and sinonasal neuroectodermal cancers was hypothesized.