Expression profiling of human gliomas by cDNA microarray

虽然人类神经胶质瘤不代表大多数恶性肿瘤，他们仍然是一种疾病，是非常难以治疗的合作，在巴罗神经研究所，凤凰城，AR的研究人员，我们正在进行cDNA微阵列实验的不同亚型的神经胶质瘤，以确定基因表达谱的诊断和预后，以及确定潜在的新的治疗靶点。两个特殊的亚型，寡树突胶质瘤和寡星形细胞瘤，是非常难以区分的正常病理技术，误诊并不罕见。这是一个非常大的问题，因为少突胶质细胞瘤有治疗方法，误诊通常会导致错误的治疗方案。因此，我们也在试图确定潜在的分子标记物，用于特异性区分这两种肿瘤类型。

Although human gliomas do not represent the majority of malignancies, they remain a disease that is very difficult to treat. In collaboration with researchers at the Barrow Neurological Institute, Phoenix, AR, we are performing cDNA microarray experiments on different subtypes of gliomas in order to identify gene expression profiles for diagnosis and prognosis, as well as to identify potential novel therapeutic targets. Two particular subtypes, oligodendoglioma and oligoastrocytoma, are very difficult to distinguish by normal pathological techniques, and misdiagnoses are not uncommon. This is a very big problem as there are treatments for oligodendroglioma, and misdiagnosis usually results in the wrong treatment regiment. Therefore, we are also trying to identify potential molecular markers to be used to specifically differentiate between these two tumor types.