Helicobacter Pylori Infection In Rural Egyptian Children

幽门螺杆菌可引起慢性活动性胃炎和消化性溃疡，并与胃腺癌的发生有关，胃腺癌是世界上第四大常见癌症。此外，还有一项建议表明，在发展中国家，儿童时期感染幽门螺杆菌会增加患慢性腹泻、营养不良和生长障碍的可能性。据估计，仅治疗幽门螺杆菌胃炎和消化性溃疡每年的全球医疗费用就超过74亿美元。在一些发展中国家，高达90%的人口在10岁前感染了幽门螺杆菌。与感染幽门螺杆菌有关的确切传播方式和风险因素在很大程度上是未知的，特别是在发展中国家。在这项研究中，分支机构调查人员计划描述埃及农村儿童从出生到三岁的人口队列中幽门螺杆菌感染的流行病学。这一队列的数据库将包括基线社会人口学特征，定期监测饮食和人体测量状况，系统监测以确定病因确定的腹泻疾病，以及系统监测以确定流行和发生的幽门螺杆菌感染。根据这些数据，将计算出幽门螺杆菌感染的特定年龄段的发病率。此外，分支机构调查员将把幽门螺杆菌的流行和事件与先前的社会人口学、卫生、行为和饮食特征以及IgA抗-H水平联系起来。哺乳婴儿摄入的母乳中的幽门螺杆菌抗体。最后，将评估持续性腹泻的比率，以及消瘦和发育迟缓的风险。到目前为止，已有279名新生儿参加了这项研究，第一名是在1998年2月1日登记的。没有更多的新生儿出生，但正在对聚集的队列进行后续行动。

Helicobacter pylori has been shown to cause chronic active gastritis and peptic ulcer disease, and it is associated with the development of gastric adenocarcinoma, the fourth most common cancer in the world. Additionally, there is a suggestion that in the developing world, infection with H. pylori in childhood increases the likelihood of developing chronic diarrhea, malnutrition, and growth failure. It is estimated that the yearly world medical cost to treat H. pylori gastritis and peptic ulcer alone exceeds $7.4 billion. In parts of the developing world, up to 90% of the population is infected with H. pylori by ten years of age. The exact mode of transmission and the risk factors associated with the acquisition of an H. pylori infection are largely unknown, especially in the developing world. In this study, Branch investigators plan to describe the epidemiology of H. pylori infection in a population-based cohort of rural Egyptian children followed from birth until three years of age. The database from this cohort will include baseline sociodemographic features, periodic monitoring of diet and anthropometric status, systematic monitoring for ascertainment of etiologically defined diarrheal illnesses, and systematic monitoring for ascertainment of prevalent and incident H. pylori infections. With these data, age-specific incidence rates for H. pylori infection will be calculated. In addition, Branch investigators will relate the occurrence of prevalent and incident H. pylori to antecedent sociodemographic, hygienic, behavioral, and dietary characteristics, and to levels of IgA anti-H. pylori antibodies in breastmilk ingested by breast-feeding infants. Finally, the rates of persistent diarrhea, and the risks of wasting and stunting will be assessed. To date 279 neonates have been enrolled into the study, the first of whom was enrolled on 2/1/98. No further newbirths are being accrued but followup of the assembled cohort is ongoing.