Arene Activation by Transition Metals

描述：(申请人提供)拟议研究的目标 是在有机合成中使用过渡金属活化的能力 芳香族底物的亲核加成反应。努力的两个主要领域 将研究内容如下：(1)烷氧基苯的三甲基铬络合物 其中烷氧基是手性的衍生物将被用作底物 用于不对称碳亲核加成反应。这样做的结果是 协议是手性取代的环己酮在高 对映体过量。(2)氯代芳烃的环戊二烯基Ru络合物 将被用来实现亲核芳香族取代，作为 复杂多肽瑞斯托菌素A苷元的全合成 与重要糖肽类抗生素万古霉素和芳香醚有关 替考拉宁。

DESCRIPTION: (provided by applicant) The objectives of the proposed research are to use in organic synthesis the ability of transition metals to activate aromatic substrates toward nucleophilic addition. Two main areas of endeavor will be studied: (1) Chromium tricarbonyl complexes of alkoxybenzene derivatives, in which the alkoxy group is chiral, will be used as substrates for asymmetric carbon nucleophile addition reactions. The outcome of this protocol is the formation of chiral substituted cyclohexenones in high enantiomeric excess. (2) Cyclopentadienylruthenium complexes of chloroarenes will be used to effect nucleophilic aromatic substitution as a key step in the total synthesis of the aglycone of ristocetin A, which is a complex peptido aryl ether related to the important glycopeptide antibiotics vancomycin and teicoplanin.