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Core C- Behavioral Core

Core C- Behavioral Core
核心C-行为核心
批准号：
6823465
负责人：
Mark G Baxter
金额：
$11.8万
依托单位：
BRIGHAM AND WOMEN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2003
资助国家：
美国
项目状态：
已结题
起止时间：
2003-09-08 至 2008-08-31
来源：
https://reporter.nih.gov/project-details/6823465
关键词：
attention behavior test biomedical facility laboratory mouse laboratory rat learning memory neuropsychological tests psychomotor function sleep sleep apnea space perception

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中文摘要
翻译
行为核心（核心C）将对SCOR的三个项目（项目2、4和5）的大鼠和小鼠进行行为分析。睡眠呼吸暂停和睡眠中断会导致人类认知障碍。行为核心将研究生理和睡眠操纵对大鼠（项目2和4）和小鼠（项目5）认知功能的影响。我们使用的任务将测试运动技能，空间学习和记忆，配对联想学习，注意力/警惕性和工作记忆/执行功能。作为核心C的具体目标，我们将开发和验证标准注意力任务（5选择系列反应时间任务）的修改版本，作为大鼠和小鼠的警觉性和觉醒测试。
英文摘要
The Behavioral Core (Core C) will perform behavioral analyses of rats and mice from three projects (Projects 2, 4, and 5) of the SCOR. Sleep apnea and sleep disruption cause cognitive impairments in humans. The Behavioral Core will examine the consequences of physiological and sleep manipulations on cognitive function in rats (Projects 2 and 4) and mice (Project 5). The tasks we use will test motor skills, spatial learning and memory, paired-associate learning, attention/vigilance, and working memory/executive function. As a Specific Aim of Core C we will develop and validate a modified version of a standard attentional task (the 5-choice serial reaction time task) as a test of vigilance and wakefulness in rats and mice.
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