Trajectory of Recovery in the Elderly

老年人康复轨迹

• 批准号: 9474553
• 负责人: Mark G Baxter
• 金额: $ 48.37万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-15 至 2020-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9474553
• 关键词: Acceleration; Adult; Affect; Age; Aging; Alzheimer' s Disease; Amnesia; Anesthesia procedures; Anesthetics; Area; Biochemistry; Brain; Caring; Cerebrovascular Circulation; Clinical; Clinical Research; Clinical assessments; Cognition; Cognitive; Comprehension; Data; Day Surgery; Development; Diagnosis; Diffusion Magnetic Resonance Imaging; Disease; Elderly; Etiology; Eye; Failure; Functional Magnetic Resonance Imaging; Functional disorder; General Anesthesia; Geriatrics; Healthcare; Home environment; Hospitals; Hypnosis; Imaging Techniques; Impaired cognition; Impairment; Individual; Inflammatory; Inpatients; Instruction; Life; Link; Literature; Longitudinal Studies; Magnetic Resonance Imaging; Measures; Modernization; Neuraxis; Neuropsychological Tests; Operative Surgical Procedures; Outcome; Participant; Patients; Perioperative; Pharmaceutical Preparations; Physiological; Play; Population; Populations at Risk; Postoperative Period; Principal Investigator; Process; Recovery; Research; Resources; Rest; Risk; Role; Self Care; Signal Transduction; Specific qualifier value; Spin Labels; Stress; Surgeon; Syndrome; Testing; Theoretical model; Time; United States National Institutes of Health; Work; animal data; clinical practice; cognitive capacity; cognitive process; cognitive recovery; cognitive reserve; cohort; cost; expectation; experience; follow-up; healthy volunteer; hospital readmission; human data; human old age (65+); improved; neuroinflammation; neurotoxic; older patient; patient population; post-operative cognitive dysfunction; postoperative delirium; prevent; public health relevance; readmission rates; volunteer; willingness

DESCRIPTION (provided by applicant): Elderly patients undergoing anesthesia and surgery frequently suffer from postoperative cognitive dysfunction (POCD) and postoperative delirium (PD). The cause of these entities is unknown; specifically it is unclear what part the anesthetics play in the development of POCD and PD. We hypothesize that elderly patient's cognitive capacities recover more slowly after receiving general anesthesia, perhaps because they have more limited cognitive reserve. A more prolonged recovery would confound diagnoses of POCD and PD and potentially puts patients who are discharged on the day of surgery at risk of not understanding postoperative instructions. The trajectory of postoperative cognitive recovery has never been explored and elderly participants have been explicitly not included in any type of emergence research. To explore this vital area we propose to study young and elderly volunteers with a combination of two state of the art neuropsychological tests (postoperative quality of recovery scale and the NIH Toolbox) and magnetic resonance imaging. Starting from baseline, we will determine multiple cognitive domains and resting state networks, treat the volunteers with general anesthesia, and then explore the recovery of the cognitive domains and alterations in functional networks. The data acquired in this project will have both clinical and theoretical relevance. Apart from distinguishing immediate drug effects from POCD and PD, characterization of the trajectory of cognitive recovery in the elderly could affect changes in clinical practice vis a vis the criteria we employ to determine, for example, hospital discharge in this population. Currently many elderly patients are (perhaps inappropriately) sent home on the day of surgery. Furthermore, characterization of the trajectory of recovery in this population would enable us to better educate our patients and those who help care for them as to the proper expectations and time course for their recovery from anesthesia. Most fundamentally, the trajectory at which various patients recover from anesthesia is the most unappreciated confounding factor in this debate on the direct and indirect effects of anesthetic drugs. The effects of the anesthesia itself are theoretically (and as we propose here, practically) separable from those due to surgery, by studying the former in the absence of the latter we can delineate the trajectory of cognitive recovery from anesthesia itself, developing an understanding that is currently lacking and yet necessary to understand POCD and PD in general.

描述（由申请人提供）：接受麻醉和手术的老年患者经常患有术后认知功能障碍（POCD）和术后谵妄（PD）。这些实体的原因尚不清楚;具体来说，目前还不清楚麻醉剂在POCD和PD的发展中起什么作用。 我们推测老年患者的认知能力在接受全身麻醉后恢复得更慢，可能是因为他们的认知储备更有限。 更长时间的恢复会混淆POCD和PD的诊断，并可能使手术当天出院的患者面临不理解术后指导的风险。 术后认知恢复的轨迹从未被探索过，老年参与者也明确不包括在任何类型的紧急研究中。 为了探索这一重要领域，我们建议研究年轻和老年志愿者与两个国家的最先进的神经心理学测试（术后恢复质量量表和NIH的神经功能缺损）和磁共振成像的组合。 从基线开始，我们将确定多个认知域和静息状态网络，对志愿者进行全身麻醉，然后探索认知域的恢复和功能网络的改变。 本项目中获得的数据将具有临床和 理论相关性。 除了将药物的即时效应与POCD和PD区分开来外，老年人认知恢复轨迹的特征可能会影响临床实践的变化，例如维斯我们采用的标准是确定老年人的出院情况。 这个人口。 目前，许多老年患者在手术当天被送回家（可能不合适）。此外，对这一人群恢复轨迹的描述将使我们能够更好地教育我们的患者和帮助护理他们的人，使他们了解麻醉恢复的适当期望和时间进程。 最根本的是，不同患者从麻醉中恢复的轨迹是关于麻醉药物直接和间接作用的辩论中最不受重视的混杂因素。 麻醉本身的影响在理论上（正如我们在这里提出的，实际上）是可分离的 通过研究前者，在没有后者的情况下，我们可以描绘出麻醉本身的认知恢复轨迹，发展出目前缺乏的理解，但对于理解POCD和PD是必要的。

项目成果

Transient changes in white matter microstructure during general anesthesia.

• DOI: 10.1371/journal.pone.0247678
• 发表时间: 2021
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Tang CY;Wang VX;Lun MY;Mincer JS;Ng JC;Brallier JW;Schwartz AE;Ahn H;McCormick PJ;Nir T;Delman B;Sano M;Deiner SG;Baxter MG
• 通讯作者: Baxter MG

Lateralisation of subcortical functional connectivity during and after general anaesthesia.

全身麻醉期间和之后皮质下功能连接的侧化。

• DOI: 10.1016/j.bja.2021.08.033
• 发表时间: 2022
• 期刊: British journal of anaesthesia
• 影响因子: 9.8
• 作者: Nir,Tommer;Raizman,Reut;Meningher,Inbar;Jacob,Yael;Huang,Kuang-Han;Schwartz,ArthurE;Brallier,JessW;Ahn,Helen;Kundu,Prantik;Tang,CheukY;Delman,BradleyN;McCormick,PatrickJ;Scarpa,Julia;Sano,Mary;Deiner,StacieG;Livny,Abig
• 通讯作者: Livny,Abig

Cognitive Recovery by Decade in Healthy 40- to 80-Year-Old Volunteers After Anesthesia Without Surgery.

• DOI: 10.1213/ane.0000000000005824
• 发表时间: 2022-02-01
• 期刊: Anesthesia and analgesia
• 影响因子: 5.7
• 作者: Baxter MG;Mincer JS;Brallier JW;Schwartz A;Ahn H;Nir T;McCormick PJ;Ismail M;Sewell M;Allore HG;Ramsey CM;Sano M;Deiner SG
• 通讯作者: Deiner SG

Resting-state functional connectivity in early postanaesthesia recovery is characterised by globally reduced anticorrelations.

麻醉后早期恢复中静息态功能连接的特点是整体反相关性降低。

• DOI: 10.1016/j.bja.2020.06.058
• 发表时间: 2020
• 期刊: British journal of anaesthesia
• 影响因子: 9.8
• 作者: Nir,Tommer;Jacob,Yael;Huang,Kuang-Han;Schwartz,ArthurE;Brallier,JessW;Ahn,Helen;Kundu,Prantik;Tang,CheukY;Delman,BradleyN;McCormick,PatrickJ;Sano,Mary;Deiner,Stacie;Baxter,MarkG;Mincer,JoshuaS
• 通讯作者: Mincer,JoshuaS