Sleep Heart Health Study

描述（由申请人提供）：在一般人群中，中年人群中睡眠呼吸障碍（SDB）的患病率估计为男性4%，女性2%，在老年人中观察到更高的比例。来自回顾性和横断面研究的越来越多的证据表明，SDB与心脑血管疾病（CVD）的存在以及随之而来的死亡率和发病率增加有关。然而，关于SDB是否为DVD发展的独立危险因素的前瞻性数据很少。睡眠心脏健康研究（SHHS）是一项纵向多中心队列研究，始于1994年，旨在确定SDB对心血管的影响。最初，SHHS招募了6,441名参与者（1996- 1998年），接受了家庭多导睡眠图（PSG）和其他心血管疾病和睡眠相关数据的采集。2001-2003年的重复PSG检查刚刚完成。死亡率和发病率的随访正在进行中，但事件发生率不足以提供SDB对CVD事件和死亡率影响的稳定估计。此外，SHHS的一个独特资源是其大约10,000个psg档案，相关评分和临床协变量数据。向科学界提供这些数据一直是SHHS的一个重要目标，并且有可能在从信号处理的新方法到识别独特流行病学关联的合作研究中实现重大利益。因此，本申请建议对SHHS队列进行额外的死亡率和发病率随访，继续进行纵向和横断面数据分析，重点关注SDB作为心血管事件和高血压的危险因素，并开发基础设施，以方便一般科学界访问SHHS PSG档案。这些目标将通过完成以下具体目标来实现：1)继续对SHHS队列进行随访，以评估SDB作为新发高血压和新发及复发性心血管疾病的危险因素；2)描述SDB的自然病史，确定RDI的变化与中期和偶发CVD事件的风险之间的关系；3)研究生活质量、日间嗜睡和机动车事故与SDB及其进展的关系；4)利用PSG数据以及先前从父母队列收集的风险因素数据，建立临床和流行病学上适用的SDB相关风险模型；5)发展基础设施，促进数据共享、协作分析和向科学界传播数据分析工具和研究成果。实现这些目标将为SDB对公众健康的影响提供重要信息

DESCRIPTION (provided by applicant): The prevalence of sleep disordered breathing (SDB) in middle aged persons in the general population is estimated to be 4 percent in men and 2 percent in women with higher rates observed in the elderly. Accumulating evidence from retrospective and cross-sectional studies suggest that SDB is associated with the presence of cardiovascular and cerebrovascular disease (CVD) and consequent increased mortality and morbidity. However, there is little prospective data indicating whether SDB is an independent risk factor for the development of DVD. The Sleep Heart Health Study (SHHS) is a longitudinal multi-center cohort study that was started in 1994 to determine the cardiovascular consequences of SDB. Initially, SHHS recruited 6,441 participants (1996-98) to undergo in-home polysomnography (PSG) and acquisition of other CVD and sleep-related data. A repeat examination with repeat PSG (2001-2003) has just been completed. Mortality and morbidity follow-up is ongoing, but event rates have been insufficient to provide stable estimates of the effect of SDB on incident CVD and mortality. Additionally, a unique resource of SHHS is its archive of approximately 10,000 PSGs, associated scoring and clinical covariate data. Providing the scientific community access to this data has always been an important goal of SHHS and has the potential to realize significant benefits in collaborative research ranging from novel methods of signal processing to identifying unique epidemiologic associations. Therefore, this application proposes additional mortality and morbidity follow-up of the SHHS cohort, continuation of longitudinal and cross-sectional data analyses focused on SDB as a risk factor for cardiovascular events and hypertension, and development of an infrastructure to facilitate access by the general scientific community to the SHHS PSG archive. These goals will be achieved by accomplishing the following specific aims: 1) to continue follow-up of the SHHS cohort in order to assess SDB as a risk factor for new-onset hypertension and new-onset and recurrent cardiovascular disease; 2) to characterize the natural history of SDB and determine how change in RDI is related to risk for interim and incident CVD events; 3) to characterize the relationship between SDB and SDB progression with quality of life, daytime sleepiness and motor vehicle accidents; 4) to use the PSG data as well as previous collected risk factor data from parent cohorts to develop a clinically and epidemiologically applicable model of risk relating to SDB; and 5) to develop an infrastructure to facilitate data sharing, collaborative analysis and dissemination of data analytic tools and research findings to the scientific community. Accomplishing these goals will provide important information concerning the public health impact of SDB