HIV Prevention Among Adolescent Women

描述（由申请人提供）：此第二阶段SBIR将开发和测试一种基于理论的，文化相关的，年龄适当的干预措施，用于降低11至14岁的种族多样性早期青春期女性的艾滋病毒风险。第二阶段将借鉴理论和经验文献以及第一阶段的进程和成果数据，起草预防内容。在一个社区专业人员小组和48名不同民族-种族的女孩的抽样审查之后，将对干预措施进行修订，并编制光盘。CD-ROM介导的干预的有效性将在一项分组随机试验中进行检查。女孩将通过大纽约市的青年服务机构招募。在随机分配研究中心到实验和对照研究组后，980名女孩将完成预测试结果测量组。实验组的年轻人将在每周六次的现场会议上与软件进行互动。两个研究组中的青少年将完成后测和6个月的随访。结果分析将确定计算机介导的干预，相对于没有干预，在减少女孩的艾滋病毒风险行为和变量假设影响这些行为的有效性。如果光盘干预措施证明有效，将通过直接营销努力和通过与面向青年的健康促进和疾病预防方案的经销商签订许可协议进行传播。

DESCRIPTION (provided by applicant): This Phase II SBIR will develop and test a theory-based, culturally relevant, and age-appropriate intervention for HIV risk reduction among ethnic-racially diverse early adolescent females aged 11 through 14 years. Drawing from the theoretical and empirical literature and Phase I process and outcome data, Phase II will draft prevention content. Following review by a panel of community-based professionals and sample of 48 ethnic-racially diverse girls, the intervention will be revised and programmed for CD-ROM delivery. The efficacy of the CD-ROM-mediated intervention will be examined in a group-randomized trial. Girls will be recruited through youth services agencies in greater New York City. Following random assignment of sites to experimental and control study arms, 980 girls will complete pretest outcome measurement batteries. Experimental arm youths will interact with the software in six weekly on-site sessions. Youths in both study arms will complete posttest and six-month follow-up batteries. Outcome analyses will determine the efficacy of the computer-mediated intervention, relative to no intervention, in reducing girls' HIV risk behaviors and variables hypothesized to influence these behaviors. Should the CD-ROM intervention prove effective, it will be disseminated through direct marketing efforts and through licensing agreements with distributors of youth-oriented health promotion and disease prevention programs.