THE HOWARD UNIVERSITY SCORE PROGRAM

描述（由申请人提供）：霍华德大学MBRS SCORE计划提出了一个创新的研究发展计划，重点关注霍华德大学的新一代初级生物医学科学家。重点是跨学科研究领域的初步发展，这将使这些新教员成为卓越的研究和培训中心。其中一个重点是人类基因变异，这一点尤其重要，因为非洲裔美国人和其他非洲散居人口的基因组中存在巨大的DNA序列变异。这里的目标是提供多学科的观点和资源，以了解人类遗传变异及其对健康和疾病的影响。第二个重点领域是神经科学，从分子的角度来看，这将进一步发展一个额外的跨学科教师小组，他们将为目前拥有神经科学中心资助的领域增加研究实力。在这个应用程序中还包含了由院系提出的关于人工肾脏和临床分子哮喘项目材料开发的令人兴奋的建议。此应用程序包含常规（16）和试点(1)项目。这些学科包括生物学、生物化学、化学、土木工程、微生物学、生理学、心理学和儿科学。霍华德大学SCORE计划的目标有三个方面：1)为人类基因组研究和神经科学目标领域跨学科生物医学研究骨干的持续发展和建立提供关键的制度支持；2)提高SCORE教师的科学生产力；3)改进对SCORE参与者和其他相关大学组成部分的程序性数据收集、分析和评估。预期这些活动将通过加强培训、提供最先进的设备、技术支助和从多学科角度研究影响少数民族人口的疾病的能力，大大提高技经科教员的研究生产力。可衡量的目标将是增加生物医学研究拨款提案、出版物和演讲的数量，这将最终加强学生的研究培训和下一代教授的准备。

DESCRIPTION (provided by applicant): The Howard University MBRS SCORE Program presents an innovative research development program, which focuses on a new cadre of junior biomedical scientists at Howard. The emphasis is on the initial development of interdisciplinary areas of research focus, which will catapult these new faculty into centers of research and training excellence. One focus is on human genetic variation, which is particularly significant because of the tremendous DNA sequence variation in the genomes of African-American, and other African Diaspora populations. The goal here is to provide multi-disciplinary perspectives and resources to understand human genetic variation and its implication in health and disease. The second area of focus is in the neurosciences, which from a molecular standpoint, will further develop an additional interdisciplinary group of faculty who will add research strength to an area which currently has a Neuroscience Center Grant. Also contained in this application are exciting proposals by faculties on the development of materials for an artificial kidney and a clinical molecular asthma program. This application contains both regular (16) and pilot (1) projects. The disciplines represented include biology, biochemistry, chemistry, civil engineering, microbiology, physiology, psychology and pediatrics. The goals of the Howard University SCORE Program are three-fold: 1) to provide critical institutional support for the continued development and establishment of interdisciplinary biomedical research cadres in the targeted areas of Human Genome Research and Neuroscience; 2) to improve the scientific productivity of SCORE faculty and; 3) to improve programmatic data collection, analysis, and assessment of SCORE participants and other associated university components. It is anticipated that these activities will significantly improve SCORE faculty research productivity through enhanced training, the provision of state-of-the-art equipment, technical support and the ability to bring multidisciplinary perspectives to bear upon diseases that disproportionately affect minority populations. The measurable objectives will be an increase in the number of biomedical research grant proposals, publications, and presentations, which will ultimately enhance student research training and preparation of the next generation professorate.