MBRS SCORE Program at Texas A&M University-Kingsville

描述(由申请人提供)：德克萨斯A&M大学金斯维尔分校的MBRS评分计划包括以下主要目标：(1)为TAMUK适当的生物医学研究环境建立和提供支持；(2)提供适当的基础设施，使参与研究人员能够检查生物医学研究的关键方面；以及(3)提供关于生物医学相关性和重要性问题的大量和重要的数据和信息。 目前资助的四个项目包括细胞凋亡、神经遗传学、毒液去整合素作用和视神经再生。第一个项目研究bcl2结合蛋白在细胞凋亡中的作用。第二个项目研究果蝇ERG钾通道的转录控制和遗传相互作用。第三个项目研究了蛇毒去整合素的作用机制。第四个项目研究硬骨鱼视神经再生的生物化学。 一个新的补充项目解决了单纯疱疹病毒1型LAT转录本的转录控制和调控及其在病毒潜伏时间中的作用。 这五个项目将共同支持两个不同系的研究，并为参与的教员提供理想的机会来扩大和加强他们各自的研究计划。研究人员个人的研究目标也将为在生物医学研究的关键方面培训本科生和研究生提供极好的机会，并为未来的生物医学研究职业生涯做好适当的准备。

DESCRIPTION (provided by applicant): The MBRS SCORE program at Texas A&M University-Kingsville consists of the following primary objectives: (1) establish and provide support for an appropriate biomedical research environment at TAMUK; (2) provide a suitable infrastructure that permits participant investigators to examine key aspects of biomedical research; and (3) provide substantial and significant data and information regarding questions of biomedical relevance and importance. The four currently funded projects encompass apoptosis, neurogenetics, venom disintegrin action, and optic nerve regeneration. The first project examines the role of BCL-2 binding proteins in apoptosis. The second project examines the transcriptional control and genetic interactions of a Drosophila ERG potassium channel. The third project examines the mechanism of action of viperid venom disintegrins. The fourth project examines the biochemistry of optic nerve regeneration in teleost fish. One new supplemental project addresses the transcriptional control and regulation of Herpes Simplex-1 LAT transcript and its role in viral latency. Together these five projects will support research in two different departments and provide ideal opportunities for the participant faculty to expand and enhance their individual research programs. The research goals of the individual investigators will also provide excellent opportunities for the training of undergraduate and graduate students in key aspects of biomedical research as well as suitable preparation for future careers in biomedical research.