Alterations of the Human SWI/SNF Complex in Lung Cancer

描述（由申请人提供）：候选人：候选人是肿瘤学 他的职业目标是成为一名翻译研究员，专注于 肺癌的分子生长抑制途径及肺癌的分子生物学研究进展 在体外和体内检测这些途径中的肿瘤异常的测定。 研究计划：肺癌是美国癌症死亡的主要原因 States.降低死亡率需要发展 基于对生长抑制途径的理解的预后标志物。 SWI/SNF综合体是满足这一关键需求的候选者，因为它是 肿瘤抑制因子视网膜母细胞瘤（RB）和 p130（RB2）。了解SWI/SNF的改变如何影响RB和p130 功能，该提案将确定下调机制 BRG和BRM（AIM 1），以阐明BRG 1在RB介导的生长中的作用 抑制（AIM 2），以确定BRG 1和BRM是否丢失或突变， 原发性肺癌（AIM 3），并确定BRG 1和BRM是否重要 p130功能（AIM 4）。本培训期的目标是提供 一个密集的研究经验，其中分子生物学的专业知识是 获得导致职业生涯作为一个双重训练的独立研究员。 环境：Lineberger卓越的研究环境 综合癌症中心将促进这些具体的成就， 目标。候选人？的培训和发展将由 专门的指导和指导的资深和有成就的科学家，博士。 伯纳德·魏斯曼。贝弗莉·米切尔医生，她有很多年了？经验 指导成功的医生/科学家，将提供保护研究 时间和翻译研究指导。因此，K 08融资期将 允许获得新的技能，从而产生一系列出版物 从而开始了独立的癌症研究生涯。

DESCRIPTION (provided by applicant): Candidate: The candidate is an Oncology fellow whose career goal is to become a translational researcher focusing on the molecular growth inhibitory pathways in lung cancer and the development of assays to detect neoplastic aberrance in these pathways both in vitro and in vivo. Research Plan: Lung cancer is the leading cause of cancer deaths in the United States. A reduction in the mortality will require the development of prognostic markers based on the understanding of growth inhibitory pathways. The SWI/SNF complex is a candidate to fill this critical need since it is likely required for function of the tumor suppressors, retinoblastoma (RB) and p130 (RB2). To understand how alterations in SWI/SNF may affect RB and p130 function, this proposal will determine the mechanisms for the down-regulation of BRG and BRM (AIM 1), to clarify the role of BRG1 in RB mediated growth inhibition (AIM 2), to determine if BRG1 and BRM are lost or mutated in primary lung cancers (AIM 3), and to determine if BRG1 and BRM are important for p130 function (AIM 4). It is the goal of this training period to provide an intense research experience whereby expertise in molecular biology is gained leading to a career as a dually trained independent researcher. Environment: The excellent research environment at the Lineberger Comprehensive Cancer Center will promote the accomplishment of these specific aims. The candidate?s training and development will be directed by the dedicated mentorship and guidance of a senior and accomplished scientist, Dr. Bernard Weissman. Dr. Beverly Mitchell, who has many years? experience in mentoring successful physician/scientists, will provide protected research time and translational research guidance. Thus, this K08 funding period will allow the acquisition of new skills resulting in a series of publications leading to an independent cancer research career.