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Hypothalamic Effects of St John's Wort Phytochemicals

Hypothalamic Effects of St John's Wort Phytochemicals
圣约翰草植物化学物质的下丘脑作用
批准号:
6668215
负责人:
MA-LI WONG
金额:
$15.92万
依托单位国家:
美国
项目类别:
财政年份:
2002
资助国家:
美国
项目状态:
已结题
起止时间:
2002-08-01 至 2003-07-31

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中文摘要
翻译
描述:这项调查将确定长期(8周) 贯叶连翘给药对大鼠ARTS的调节作用类似于 与长期服用原型抗抑郁药物不同。 将获得的其他数据包括艺术上的任何变化的性质 贯叶连翘的病程及长期给药情况 调节被认为在严重抑郁期间被激活的基因的表达 精神障碍(MDD)。这项研究将提供信息,以提供 关于后续阶段I/II的剂量和作用机制的指导 学习。
英文摘要
DESCRIPTION: This investigation will determine if the long term (8 weeks) administration of Hypericum perforatum to rats regulates ARTs similarly to, or differently from, long-term administration of prototypic antidepressant drugs. Additional data to be gained include the nature of any changes in ARTs during the course of Hypericum perforatum and whether this long-term administration regulates expression of genes thought to be activated during major depressive disorder (MDD). This study will offer information to be utilized to provide guidance in terms of dose and mechanism of action for subsequent phase I/II studies.
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