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Chinese Red Yeast Rice Comparison to Lovastatin

Chinese Red Yeast Rice Comparison to Lovastatin
中国红曲米与洛伐他汀的比较
批准号：
6666250
负责人：
David Heber
金额：
$15.92万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2002
资助国家：
美国
项目状态：
已结题
起止时间：
2002-08-01 至 2003-07-31
来源：
https://reporter.nih.gov/project-details/6666250
关键词：
alternative medicine antiatherogenic agent antihypercholesterolemic agent clinical research drug discovery /isolation drug screening /evaluation genetic transcription genetically modified animals human subject laboratory mouse lovastatin male oxoacid lyase pharmacokinetics plant extracts rice tissue /cell culture yeasts

项目摘要

项目成果

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中文摘要
翻译
描述：该项目将评估对胆固醇生物合成的影响。 和动脉粥样硬化病变形成，从 一种酵母发酵的大米，与洛伐他汀相比。这将通过以下方式实现 检测HMG-COA基因在HepG2细胞中的转录上调 含有荧光素酶报告基因。第二个终点将是队形 动脉粥样硬化病变和测量载脂蛋白E的血胆固醇水平 基因敲除老鼠。最终研究将分析该混合物的生物利用度。 来自红曲大米和人类志愿者纯洛伐他汀的Monacolins。
英文摘要
Description: This project will evaluate the effect, on cholesterol biosynthesis and atherosclerotic lesion formation, of a mixture of monacolins isolated from a yeast fermented rice compared to Lovastatin. This will be accomplished by measuring up-regulation of HMG-COA gene transcription in HEPG2 cell constructs containing a luciferase reporter gene. A second end point will be the formation of atherosclerotic lesions and measuring blood cholesterol levels in ApoE knockout mice. The final study will assay the bioavailability of the mixture of monacolins from red yeast rice and of pure Lovastatin in human volunteers.
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