PACIFIC OVARIAN CANCER RESEARCH CONSORTIUM

太平洋卵巢癌研究联盟（POCRC）是由弗雷德哈钦森癌症研究中心（FHCRC）领导的五个非营利组织组成的联盟，包括华盛顿大学（UW），瑞典医学中心（SMC），太平洋西北研究所（PNRI）和雪松西奈医学中心（CSMC）。POCRC由一群来自不同学科的敬业和热情的科学家组成，他们聚集在一起解决我们认为控制卵巢癌最关键的问题。我们已经确定了五个领域，在这些领域我们有机会发挥作用。第一个是鉴定和阐明介导化学抗性的基因的功能（项目1）。第二个是开发制造最终用于卵巢癌预防的核酸疫苗的方法（项目2）。第三是开发评估卵巢风险的工具，以支持筛查和预防试验，这些试验将证明干预措施降低卵巢癌发病率和死亡率的有效性（项目3）。第四个是发展统计方法，用于选择卵巢癌标志物纳入筛查组，并根据妇女个人情况调整筛查组的使用，以提高筛查的效率和成本效益（项目4）。第五是进行一项确定性研究，以证明旨在改善晚期卵巢癌患者生活质量的促进性团体咨询干预的有效性或缺乏有效性（项目5）。该计划的总体挑战是保持科学家之间的高水平互动，并在整个团队中迅速交流新发现。领导核心将作为科学互动、指导、指导和项目开发的基础。临床核心将提供协调和全面的程序，以便与医生合作，确定符合条件的妇女参加SPORE的各种研究和活动，并与医生互动，确定符合条件的妇女参加SPORE的各种研究和活动，并与华盛顿州的医生和医疗保健提供者互动，将研究结果反馈给社区。标本中心将收集、管理和分析组织和血液制品，以支持SPORE研究项目。

The Pacific Ovarian Cancer Research Consortium (POCRC) is a consortium of five non-profit organizations led by the Fred Hutchinson Cancer Research Center (FHCRC), including the University of Washington (UW), Swedish Medical Center (SMC), Pacific Northwest Research Institute (PNRI), and Cedars Sinai Medical Center (CSMC). POCRC consists of a group of dedicated and enthusiastic scientists from a variety of disciplines who have come together to address the issues that we view as most critical in controlling ovarian cancer. We have identified five areas where opportunities exist for us to make a difference. The first is the identification and elucidation of the function of the genes that mediate chemo-resistance (Project 1). The second is the development of methods to create nucleic acid vaccines to be used eventually in ovarian cancer prevention (Project 2). The third is development of tools to estimate ovarian risk to support the screening and prevention trials that will be required to demonstrate the efficacy of interventions to reduce incidence and mortality from ovarian cancer (Project 3). The fourth is the development of statistical methods for selecting ovarian cancer markers to be included in a screening panel, and for tailoring the use of the panel to the individual woman to improve the efficacy and cost-effectiveness of screening (Project 4). The fifth is performance of a definitive study to demonstrate the efficacy or lack thereof of a facilitated group counseling intervention designed to improve advanced ovarian cancer patients' quality of life (Project 5). The overall challenge of the program is to maintain a high level of interaction among scientists and rapidly communicate novel discoveries throughout the group. A Leadership Core will act as the foundation for scientific interaction, direction, mentoring, and program development. A Clinical Core will provide coordinate and comprehensive procedures for working with physicians to identify eligible women for enrollment in various research studies and activities in the SPORE and interact with the physicians to identify eligible women for enrollment in various research studies and activities in the SPORE and interact with the physicians and health care providers in Washington State to translate the research findings back to the community. A Specimen Core will collect, manage, and analyze tissue and blood products in support of the SPORE research projects.