Cell and Process Engineering for Recombinant Antibody Production

随着正在开发的重组蛋白质疗法数量的大幅增加，以及其分子结构的多样化，需要开发既能快速产生产品又能提高可制造性的细胞和过程工程技术。该项目将利用谢菲尔德大学和绝对抗体有限公司的重要专业知识，创建新的瞬时生物生产系统，在哺乳动物细胞中以低成本和可扩展的方式生产各种重组蛋白。谢菲尔德将进行核心、新颖的技术创新，然后在绝对抗体(https://absoluteantibody.com).)将其转化为商业实践因此，该项目是研究生接受世界领先的生物制造研发培训的绝佳机会，并有机会将培训减少到位于N8地区的快速扩张的中小企业的核心商业实践中。

A vast expansion in the number of recombinant protein therapeutics in development, with a diversification in their molecular architecture necessitates the development of cell and process engineering technologies that can both rapidly generate product and improve manufacturability. This project will harness significant expertise at both The University of Sheffield and Absolute Antibody Ltd. to create new transient bioproduction systems for cost-effective and scalable production of diverse recombinant proteins in mammalian cells. Core, novel technological innovation will occur at Sheffield and then be translated into commercial practice at Absolute Antibody (https://absoluteantibody.com). This project therefore represents an excellent opportunity for a postgraduate student to receive training in world-leading R&D for biomanufacturing with the opportunity to reduce this to core commercial practice in a rapidly expanding SME based in the N8 region.