NEW STRATEGIES FOR IMPROVED IMPRINTED POLYMERS

描述：(主要研究人员摘要)分子印迹聚合物 是高度交联的有机基质，可以很容易地合成成具有 多种分子、大分子的结合亲和力和选择性 甚至是细胞。建议应用一种新的战略来改善 分子印迹聚合物(MIP)的选择性。有选择性的 印迹聚合物的后改性导致材料具有更多的 其结合部位的同质性和选择性。原则是 选择性地灭活低亲和力位点，从而得到更高的MIP 总的结合亲和力和选择性。这一战略与以前的战略不同 试图改善MIP的属性，这些MIP都依赖于 压印工艺的优化。对健康领域的好处将是 是纯度更高、传感器便宜的药物和药品，可以 为特定分析物量身定做。

DESCRIPTION: (Principal Investigator's Abstract) Molecularly imprinted polymers are highly crosslinked organic matrixes that can be readily synthesized to have binding affinity and selectivity for a wide range of molecules, macromolecules and even cells. Proposed is the application of a novel strategy to improve the selectivities of molecularly imprinted polymers (MIPs). Selective post-modification of the imprinted polymers leads to a material with more homogeneity and selectivity among its binding sites. The principle is to selectively inactivate low affinity sites so that the resulting MIP has higher overall binding affinity and selectivity. This strategy differs from previous attempts to improve the properties of MIPs which have all relied on optimization of the imprinting process. The benefits to the health field will be drugs and pharmaceuticals of higher purity and inexpensive sensors that can be tailored to particular analytes.