AGING AND CANCER PROGRAM

产品说明：（申请人的描述）我们建议在威斯康星大学麦迪逊综合癌症中心（UWCCC）内建立“衰老与癌症计划”。 我们处于独特的地位，因为这个应用程序依赖于一个大型的，不断增长的和多样化的老龄化研究计划，将与UWCCC的调查人员和资源进行有效的互动提供了坚实的基础。关于老龄化的社会学，心理学，健康服务和生物医学方面的研究长期以来一直在威斯康星大学麦迪逊分校进行，并正在大力扩展，这一点可以通过NIA赠款支持的令人印象深刻的组合来证明。 这些研究非常多样化，包括NIA对三个计划项目的支持：两个大型，长期，纵向人口为基础的研究（"威斯康星州纵向研究"和"健康和疾病的综合途径-MIDUS"），以及"恒河猴的饮食限制"。 老龄化研究也得到了强大单位的支持，包括华盛顿大学老龄化研究所、医学部老年医学和老年学科以及VA GRECC。 其他重要的支持来自其他NIH资助的中心，包括身心相互作用研究（NIMH）和健康与衰老人口统计学（NIA）以及威斯康星州跨学科分子成像中心（NCI）。 UW老龄化社区和UWCCC之间的现有联系，虽然不是完全没有，但主要是生物医学的。 然而，我们在衰老和癌症方面都拥有强大的科学优势，因此我们无法更好地在这两个领域之间创造和建立协同效应。 此外，过去阻碍这种合作的障碍已不复存在，而且已承诺为建立这一新方案提供重要的机构支持。 因此，在Richard Weindruch博士的领导下，作为一名长期研究啮齿动物模型中自发性晚期癌症的老年病学家，我们组建了一个由癌症生物学家、老年病学家、肿瘤学家、老年病学家和人口科学家组成的小组，以解决五个主题领域：（Maureen Smith，MD，PhD，MPH [领导者]，加里夏皮罗，MD [共同领导者]）;科摩罗的影响（Sanjay Asthana，医学博士，James Stewart，医学博士）;心理社会问题（Susan Heidrich，博士，Carol Ryff，博士）;姑息治疗（James Cleary，医学博士，Elizabeth克雷默，博士）;以及衰老和癌症生物学（Richard Weindruch，博士，大卫Jarrard，医学博士）。 我们认为，鉴于人口现实和解决关键知识差距的机会，该计划的创建及其所培育的研究至关重要。

DESCRIPTION: (Applicant's Description) We propose to establish the "Aging and Cancer Program" within the University of Wisconsin-Madison Comprehensive Cancer Center (UWCCC). We are uniquely positioned to do so as this application rests on the strong foundation provided by a large, growing and diverse aging research program that will interact productively with the investigators and resources of the UWCCC. Studies on sociological, psychological, health services and biomedical aspects of aging have long been pursued at the UW-Madison and are vigorously expanding as evidenced by an impressive portfolio of NIA grant support. These studies are incredibly diverse and include NIA support for three Program Projects: two large, long-term, longitudinal population-based studies ("Wisconsin Longitudinal Study" and "Integrative Pathways to Health and Illness- MIDUS"), and "Dietary Restriction in Rhesus Monkeys". Aging research is also supported by strong units including the UW's Institute on Aging, the Department of Medicine's Section of Geriatrics and Gerontology, and the VA GRECC. Additional important support is derived from other NIH-funded Centers including those for the Study of Mind-Body Interaction (NIMH) and Demography of Health and Aging (NIA) and the Wisconsin Interdisciplinary Molecular Imaging Center (NCI). The existing links between the UW aging community and the UWCCC, while not entirely absent, are largely biomedical. However, we have powerful scientific strengths in both aging and cancer such that we could not be better positioned to create and build synergies between these two areas. Further, past barriers to such collaboration no longer exist and significant institutional support for building this new program has been committed. Accordingly, under the leadership of Richard Weindruch, Ph.D., a gerontologist who has long investigated spontaneous late-life cancers in rodent models, we have formed a group of cancer biologists, gerontologists, oncologists, geriatricians and population scientists to address five thematic areas: Patterns of Care (Maureen Smith, MD, PhD, MPH [Leader], Gary Shapiro, MD [Co-Leader]); Effects of Comorbidity (Sanjay Asthana, MD, James Stewart, MD); Psychosocial Issues (Susan Heidrich, PhD, Carol Ryff, PhD); Palliative Care (James Cleary, MD, Elizabeth Kramer, PhD); and Biology of Aging and Cancer (Richard Weindruch, PhD, David Jarrard, MD). We view the creation of this Program and the research it will nurture to be vital in view of demographic realities and opportunities to address critical knowledge gaps.