DIETARY RESTRICTION AND AGING

饮食限制和衰老

• 批准号: 8173062
• 负责人: Richard Weindruch
• 金额: $ 8.26万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8173062
• 关键词: Age; Aging; Aging-Related Process; Animals; Atlases; Biochemical; Biological Markers; Biology of Aging; Caloric Restriction; Calories; Cardiovascular system; Cell Aging; Collection; Computer Retrieval of Information on Scientific Projects Database; Controlled Study; Diabetes Mellitus; Diet; Disease; Eating; Energy Intake; Exhibits; Fasting; Fatty acid glycerol esters; Female; Funding; Gene Expression Profiling; Glucose; Grant; Health; Health Services Research; Human; Hypertension; Incidence; Institution; Longevity; Macaca mulatta; Malignant Neoplasms; Menstrual cycle; Metabolic; Monkeys; Mouse Strains; Mus; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Onset of illness; Osteoporosis; Phase; Physiological; Population; Primates; Process; Research; Research Personnel; Resources; Risk; Rodent; Science; Services; Skeletal Muscle; Source; Spondylarthritis; Staging; United States National Institutes of Health; Vascular Diseases; age related; atherogenesis; basal insulin; base; cell age; diabetic; dietary antioxidant; dietary restriction; longitudinal analysis; low density lipoprotein inhibitor; mortality; muscle form; neuroimaging; nonhuman primate; oxidative damage; programs; sarcopenia

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: To explore the possibility that dietary restriction retards aging processes in a nonhuman primate species, this Program Project has provided a wealth of new information about the biology of aging and how the manipulation of diet can influence the process of growing old. Rhesus monkeys eating 30 percent fewer calories of a nutritionally complete diet exhibit better health than study controls. Reduced caloric intake seems to slow basic aging processes and may extend the maximum life span in primates, as has been shown in rodents. Diabetes develops less frequently in monkeys on a restricted diet. Animals allowed to eat freely have a greater incidence of diabetic or pre-diabetic conditions. Fasting basal insulin and glucose concentrations are lower in monkeys on a restricted diet. Both fat mass and fat-free mass were lower in monkeys on a restricted diet. Monkeys on a reduced-calorie diet have fewer signs of spinal arthritis, a condition that manifests itself with age in both rhesus monkeys and humans. Fewer calories may reduce the risk of vascular disease. Caloric restriction altered circulating LDL in a manner that may inhibit atherogenesis. Caloric restriction retards several age-dependent physiological and biochemical changes in skeletal muscle, including oxidative damage. Controlled caloric restriction has not disrupted menstrual cycles of female monkeys. The next period of study should be even more insightful as the oldest monkeys in the study are now truly old. During this phase, age-related diseases and disorders appear more frequently, including adult-onset diabetes, osteoporosis, cancers, obesity, hypertension and the loss of skeletal muscle mass. This research used Animal Services and Research Services. PUBLICATIONS: Anderson RM, Shanmuganayagan D, Weindruch R: Caloric restriction and aging: studies in mice and monkeys. Toxicol. Pathol. 37:47-51, 2009. Colman RJ, Anderson RM, Johnson SC, Kastman EK, Kosmatka KJ, Beasley TM, Allison DB, Cruzen C, Simmons HA, Kemnitz JW, Weindruch R: Caloric restriction delays disease onset and mortality in rhesus monkeys. Science 325:201-4, 2009. Cruzen C, Colman RJ. Effects of caloric restriction on cardiovascular aging in non-human primates and humans. Clin. Geriatr. Med. 25(4):733-743, 2009. McKiernan SH, Colman R, Lopez M, Beasley TM, Weindruch R, Aiken JM: Longitudinal analysis of early stage sarcopenia in aging rhesus monkeys. Exp. Gerontol. 44:170-6, 2009. McLaren DG, Kosmatka KJ, Oakes TR, Kroenke CD, Kohama SG, Matochik JA, Ingram DK, Johnson SC: A population-average MRI-based atlas collection of the rhesus macaque. Neuroimage 45:52-9, 2009. Park SK, Kim K, Page GP, Allison DB, Weindruch R, Prolla TA: Gene expression profiling of aging in multiple mouse strains: identification of aging biomarkers and impact of dietary antioxidants. Aging Cell 8:484-95, 2009. Rezzi S, Martin FP, Shanmuganayagam D, Colman RJ, Nicholson JK, Weindruch R: Metabolic shifts due to long-term caloric restriction revealed in nonhuman primates. Exp. Gerontol. 44:356-62, 2009.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 目的：为了探索饮食限制延缓非人类灵长类物种衰老过程的可能性，本项目提供了丰富的关于衰老生物学的新信息，以及饮食控制如何影响衰老过程。 在营养丰富的饮食中，恒河猴摄入的卡路里少30%，比研究对照组的健康状况更好。减少卡路里摄入量似乎可以减缓灵长类动物的基本衰老过程，并可能延长灵长类动物的最长寿命，就像在啮齿动物身上所显示的那样。限制饮食的猴子患糖尿病的几率较低。允许自由进食的动物患糖尿病或糖尿病前期疾病的几率更高。限制饮食的猴子的空腹基础胰岛素和葡萄糖浓度较低。在限制饮食的猴子中，脂肪质量和脱脂质量都较低。低卡路里饮食的猴子较少出现脊椎关节炎的迹象，这种疾病在恒河猴和人类身上都会随着年龄的增长而表现出来。较少的卡路里可能会降低患血管疾病的风险。热量限制改变了循环中的低密度脂蛋白，可能会抑制动脉粥样硬化的形成。卡路里限制延缓了骨骼肌中几个与年龄相关的生理和生化变化，包括氧化损伤。受控的热量限制并没有扰乱雌性猴子的月经周期。下一阶段的研究应该更有洞察力，因为研究中年龄最大的猴子现在已经真正老了。在这一阶段，与年龄相关的疾病和障碍出现得更频繁，包括成人起病的糖尿病、骨质疏松症、癌症、肥胖、高血压和骨骼肌块减少。 这项研究使用了动物服务和研究服务。 出版物： Anderson RM，Shanmuganayagan D，Weindruch R：卡路里限制与衰老：老鼠和猴子的研究。托昔康。帕托尔。2009年，37：47-51。 Colman RJ、Anderson RM、Johnson SC、Kastman EK、Kosmatka KJ、Beasley TM、Allison DB、Cruzen C、Simmons HA、Kemnitz JW、Weindruch R：限制热量可延迟恒河猴的疾病发生和死亡。科学325：201-4,2009。 克鲁森·C，科尔曼·RJ。限制热量摄入对非人类灵长类和人类心血管衰老的影响。克莱恩。老妇人。地中海医院。25(4)：733-743,2009。 McKiernan SH，Colman R，Lopez M，Beasley TM，WeindruchR，Aiken JM：老年恒河猴早期石棺减少的纵向分析。实验杰隆托。44：170-6,2009. McLaren DG，Kosmatka KJ，Okers tr，Kroenke CD，Kohama SG，Matochik JA，Ingram DK，Johnson SC：恒河猴基于MRI的种群平均图谱集合。神经影像45：52-9,2009。 Park SK，Kim K，Page GP，Allison DB，Weindruch R，Prolla TA：多个小鼠品系衰老的基因表达谱：衰老生物标志物的识别和饮食抗氧化剂的影响。老龄细胞8：484-95,2009。 雷兹·S，马丁·FP，Shanmuganayagam D，Colman RJ，Nicholson JK，Weindruch R：在非人类灵长类动物中发现的长期热量限制引起的代谢变化。实验杰隆托。44：356-62,2009。