UCSF CC/SFSU Collaborative--Cancer Research and Training

这项合作是在加州大学、旧金山弗朗西斯科癌症中心（UCSFCC）和旧金山弗朗西斯科州立大学（SFSU）之间进行的。该中心将开展两项试验研究项目和两项规划和发展活动，以便在癌症生物学方面进行合作性本科生和/或博士前研究培训。合作试点研究项目将涉及SFSU/UCSFCC调查员的两个团队;这两个合作将包括一个新聘请的SFSU。生物学助理教授和高级UCSF教员谁也是UCSFCC的成员。UCSF教授Elizabeth Blackburn博士将与Sally帕西翁博士一起担任导师和共同研究者。对裂殖酵母DNA复制和修复突变体的端粒末端进行表征。Wilfred Denetclaw博士（任命为SFSU生物学助理教授，2000年9月生效）将由他的前UCSF博士后导师Charles Ordahl教授指导。他们的合作研究项目将集中在生物标志物的dermomyotomal肌节祖细胞和他们的上皮细胞到间充质转化为肌节层。每个合作试点研究项目中内置的研究问题和指导承诺旨在导致在此P-20规划补助金的第三年期间提交RO 1提案。学生研究培训将是本提案规划和发展部分的重点。一个试点计划和发展活动将使用SFSU和UCSFCC教师委员会联合开发一个更积极和协调的安置过程/计划，以招募SFSU本科生（MARC和MBRS- RISE）和SFSU MA/MS学位（NIH Bridge和MBRS-RISE）学生进入UCSFCC实验室，特别是将审查和评估过去的参与，1）SFSU本科生（MARC和MBRS-RISE）在UCSF夏季研究经验和2）SFSU RISE的学年论文研究经验）在UCSF夏季研究经验和2）SFSU MA/硕士学位的学生，他们的研究是在UCSF教师实验室执行的基础上，制定一项行动计划，将提供一个良好的培训经验，在一个环境中渗透着癌症生物学的重点。第二个试点规划和发展活动将致力于在P-20项目的第三年开展必要的基础工作，以制定R-25 E或R-25 T或T- 32联合博士前培训提案。实现这一目标将需要通过联合UCSFCC-SFSU教师会议和务虚会认真规划，以1）确定和优先考虑短期和长期的博士前学生癌症研究培训目标，2）在R-25 E或R-25 T或T-32资助机制的指导方针内制定相互接受的合作博士前癌症研究培训计划。任何最终提案的核心要素将是招聘和保留战略的应用，这将导致代表性不足的战略的入学人数增加，这将导致代表性不足的少数民族的入学人数增加，并从博士毕业。程序.

This Collaborative is between the University of California, San Francisco Cancer Center (UCSFCC) and San Francisco State University (SFSU). It will initiate two pilot Research Projects and two Planning and Development activities for collaborative undergraduate and/or pre- doctoral research training in cancer biology. The collaborative pilot Research Projects will involve two teams of SFSU/UCSFCC investigators; both collaborations will consist of a newly hired SFSU. Assistant Professor of Biology and a senior UCSF faculty member who is also a member of the UCSFCC. UCSF Professor Elizabeth Blackburn, Ph.D. will serve as mentor and co-investigator with Sally Pasion, Ph.D. to characterize telomere ends in fission yeast DNA replication and repair mutant. Wilfred Denetclaw, Ph.D. (appointment as a SFSU Assistant Professor of Biology effective September 2000) will be mentored by his former UCSF post-doctoral supervisor Professor Charles Ordahl. Their collaborative Research Project will focus on the biological markers for dermomyotomal myotome progenitor cells and their epithelial-to-mesenchymal transition into the myotome layer. The research questions and mentoring commitments built into each collaborative pilot Research project are designed to result in the submission of RO1 proposals during the third year of this P-20 planning grant. Student research training will be the focus for the Planning and Development section of this proposal. One pilot Planning and Development activity will use a joint SFSU and UCSFCC faculty committee to develop a more aggressive and concerted placement process/program to recruit SFSU undergraduate (MARC and MBRS- RISE) and SFSU MA/MS degree (NIH Bridge and MBRS-RISE) students into UCSFCC laboratories specifically will review and evaluate the past involvement of, 1) SFSU undergraduates (MARC and MBRS- RISE) in UCSF summer research experiences and 2) the academic year thesis research experiences of SFSU RISE) in UCSF summer research experiences and 2) the academic year thesis research experiences of SFSU MA/MS degree students whose research was executed in UCSF faculty laboratories as a basis to develop an action plan that will provide an excellent training experience in an environment permeated with a cancer biology focus. The second pilot Planning and Development activity will be directed at doing the ground work necessary to develop a joint R-25E or R-25T or T- 32 pre-doctoral training proposal during the third year of this P-20 project. Realization of this goal will require serious planning through joint UCSFCC-SFSU faculty meetings and retreats to 1) identify and prioritize short and long-term pre-doctoral student cancer research training goals and 2) develop a mutually acceptable collaborative pre- doctoral cancer research training program within the guidelines of a R- 25E or R-25T or T-32 funding mechanism. A core element of any final proposal will be the application of recruitment and retention strategies that will result in an increased enrollment of under-represented strategies that will result in an increased enrollment of under-represented minorities into and graduation from Ph.D. programs.