UCSF CC/SFSU Collaborative--Cancer Research and Training

UCSF CC/SFSU 合作--癌症研究和培训

• 批准号: 6336000
• 负责人: JOHN A WATSON
• 金额: $ 7.38万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-05-01 至 2004-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6336000
• 关键词: fungal genetics; vertebrate embryology

This Collaborative is between the University of California, San Francisco Cancer Center (UCSFCC) and San Francisco State University (SFSU). It will initiate two pilot Research Projects and two Planning and Development activities for collaborative undergraduate and/or pre- doctoral research training in cancer biology. The collaborative pilot Research Projects will involve two teams of SFSU/UCSFCC investigators; both collaborations will consist of a newly hired SFSU. Assistant Professor of Biology and a senior UCSF faculty member who is also a member of the UCSFCC. UCSF Professor Elizabeth Blackburn, Ph.D. will serve as mentor and co-investigator with Sally Pasion, Ph.D. to characterize telomere ends in fission yeast DNA replication and repair mutant. Wilfred Denetclaw, Ph.D. (appointment as a SFSU Assistant Professor of Biology effective September 2000) will be mentored by his former UCSF post-doctoral supervisor Professor Charles Ordahl. Their collaborative Research Project will focus on the biological markers for dermomyotomal myotome progenitor cells and their epithelial-to-mesenchymal transition into the myotome layer. The research questions and mentoring commitments built into each collaborative pilot Research project are designed to result in the submission of RO1 proposals during the third year of this P-20 planning grant. Student research training will be the focus for the Planning and Development section of this proposal. One pilot Planning and Development activity will use a joint SFSU and UCSFCC faculty committee to develop a more aggressive and concerted placement process/program to recruit SFSU undergraduate (MARC and MBRS- RISE) and SFSU MA/MS degree (NIH Bridge and MBRS-RISE) students into UCSFCC laboratories specifically will review and evaluate the past involvement of, 1) SFSU undergraduates (MARC and MBRS- RISE) in UCSF summer research experiences and 2) the academic year thesis research experiences of SFSU RISE) in UCSF summer research experiences and 2) the academic year thesis research experiences of SFSU MA/MS degree students whose research was executed in UCSF faculty laboratories as a basis to develop an action plan that will provide an excellent training experience in an environment permeated with a cancer biology focus. The second pilot Planning and Development activity will be directed at doing the ground work necessary to develop a joint R-25E or R-25T or T- 32 pre-doctoral training proposal during the third year of this P-20 project. Realization of this goal will require serious planning through joint UCSFCC-SFSU faculty meetings and retreats to 1) identify and prioritize short and long-term pre-doctoral student cancer research training goals and 2) develop a mutually acceptable collaborative pre- doctoral cancer research training program within the guidelines of a R- 25E or R-25T or T-32 funding mechanism. A core element of any final proposal will be the application of recruitment and retention strategies that will result in an increased enrollment of under-represented strategies that will result in an increased enrollment of under-represented minorities into and graduation from Ph.D. programs.

这项合作是由加州大学旧金山癌症中心（UCSFCC）和旧金山州立大学（SFSU）共同完成的。它将启动两个试点研究项目和两个规划和发展活动，以合作癌症生物学的本科生和/或博士前研究培训。合作试点研究项目将涉及两组SFSU/UCSFCC研究人员；这两项合作都将由新聘请的旧金山州立大学组成。生物学助理教授，加州大学旧金山分校高级教员，同时也是加州大学旧金山分校委员会成员。UCSF教授Elizabeth Blackburn博士将与Sally Pasion博士一起担任导师和共同研究员，以表征分裂酵母DNA复制和修复突变体的端粒末端。Wilfred Denetclaw博士（2000年9月被任命为旧金山州立大学生物学助理教授）将由他的前UCSF博士后导师Charles Ordahl教授指导。他们的合作研究项目将集中在真皮细胞瘤肌瘤祖细胞的生物学标记及其上皮到间充质向肌瘤层的转化。每个合作试点研究项目中的研究问题和指导承诺旨在在P-20规划赠款的第三年提交RO1提案。学生研究训练将是本提案规划与发展部分的重点。一项试点计划和发展活动将使用旧金山州立大学和UCSFCC联合的教师委员会来制定一个更积极和协调的安置过程/计划，以招募旧金山州立大学本科生（MARC和MBRS-RISE）和旧金山州立大学硕士/硕士学位（NIH Bridge和MBRS-RISE）的学生到UCSFCC实验室，具体来说，将审查和评估过去的参与，1) SFSU本科生（MARC和MBRS- RISE）在UCSF的夏季研究经历；2)SFSU RISE的学年论文研究经历；2)SFSU MA/MS学位学生的学年论文研究经历，他们的研究在UCSF的教师实验室进行，作为制定行动计划的基础，该行动计划将在充满癌症生物学焦点的环境中提供出色的培训经历。第二个试点计划和发展活动将在P-20项目的第三年进行必要的基础工作，以制定联合R-25E或R-25T或T- 32博士前培训建议。要实现这一目标，需要通过联合加州大学旧金山分校和旧金山州立大学的教师会议和务实性会议进行认真的规划：1)确定和优先考虑短期和长期的博士生癌症研究培训目标；2)在R- 25E或R- 25t或T-32资助机制的指导下，制定一个双方都能接受的合作博士前癌症研究培训计划。任何最终提案的核心要素都将是招聘和保留策略的应用，这将导致增加代表性不足的策略的入学率，从而增加代表性不足的少数民族进入和从博士项目毕业的入学率。