UCSFCC/SFSU Collaborative Cancer Research and Training

本次合作由加州大学旧金山癌症中心（UCSFCC）和旧金山州立大学（SFSU）共同完成。它将启动两个试点研究项目和两个规划和发展活动，以促进未来的合作博士前研究培训。试点研究项目将涉及两组SFSU/UCSFCC研究人员；这两项合作是由新聘请的SFSU生物学助理教授和UCSF高级教员（也是UCSFCC的成员）之间进行的，UCSF教授Elizabeth Blackburn博士将与Sally Passion博士一起指导和共同研究裂变酵母DNA复制和修复突变体的端粒末端。Wilfred Denetclaw博士（2000年9月被任命为旧金山州立大学生物学助理教授）将由前UCSF博士后导师Charles Ordahl教授指导。他们的合作研究项目将集中在真皮细胞瘤肌瘤祖细胞的生物学标记及其上皮到间充质向肌瘤层的转化。每个合作试点项目的研究问题和指导承诺旨在测试在P-20规划补助金的第三年提交的RO1提案。学生研究训练将是本提案规划和发展部分的重点。一项试点计划和发展活动将使用SFSU和UCSFCC的一群教师，为SFSU本科生（MARC和MBRS-RISE）和SFSU硕士/硕士学位（NIH Bridge和MBRS-RISE）学生制定一个更积极和协调一致的安置过程/计划，专门进入UCSFCC实验室。为了在2001年6月启动这项活动，合作教师计划委员会审查和评估了1)SFSU本科生（MARC和MBRS-RISE）在UCSF的夏季研究经历和2)在UCSF教师实验室进行学术论文研究的过去参与情况，并制定了一项行动计划，该计划将在充满癌症关注的环境中发展强大的研究培训经验。第二个试点规划和发展活动的目标是在P-20项目的第三年期间提交一份联合R-25E或R-25T或T-32博士前培训建议。要实现这一目标，需要通过联合ucsf - sfsu教师会议和务实性会议进行认真的规划，1)确定和优先考虑短期和长期博士生癌症研究培训目标；2)根据R-25E或R-25T或T-32资助机制的指导方针，制定一个双方都能接受的合作博士前癌症研究培训计划。任何最终提案的核心要素都将是招聘和保留策略的应用，这将导致博士项目中代表性不足的少数民族的入学率增加。

DESCRIPTION This Collaborative is between the University of California, San Francisco Cancer Center (UCSFCC) and San Francisco State University (SFSU). It will initiate two pilot Research Projects and two Planning and Developmental activities for future collaborative pre-doctoral research training. The pilot Research Projects will involve two teams of SFSU/UCSFCC investigators; both collaborations is between a newly hired SFSU Assistant Professor of Biology and a senior UCSF faculty member who is also a member of the UCSFCC, UCSF Professor Elizabeth Blackburn, Ph.D. will serve as mentored and co-investigator with Sally Passion, Ph.D. to characterize telomere ends in fission yeast DNA replication and repair mutants. Wilfred Denetclaw, Ph.D. (Appointment as a SFSU Assistant Professor of Biology effective September 2000) will be mentored by this former UCSF post-doctoral supervisor Professor Charles Ordahl. Their collaborative Research Project will focus on the biological markers for dermomyotomal myotome progenitor cells and their epithelial-to-mesenchymal transition into the myotome layer. The research questions and mentoring commitments build into each collaborative pilot project are designed to test in the submission of RO1 proposals during the third year of this P-20 planning grant. Student research training will be the focus for the Planning and Developmental components of this proposal. One pilot Planning and Development activity will use a cohort of SFSU and UCSFCC faculty to develop a more aggressive and concerted placement process/program for SFSU undergraduate (MARC and MBRS-RISE) and SFSU MA/MS degree (NIH Bridge and MBRS-RISE) students into UCSFCC laboratories specifically. In order to commence this activity in June 2001, the collaborative faculty planning committee review and evaluate the past involvement of, 1) SFSU undergraduates (MARC and MBRS-RISE) in summer research experiences in UCSF and 2) whose academic thesis research was executed in UCSF faculty laboratories and develop an action plan that will develop a strong research training experience in an environment permeated with a cancer focus. The second pilot Planning and Development activity will be directed at the submission of a joint R-25E or R-25T or T-32 pre-doctoral training proposal during the third year of this P-20 project. Realization of this goal will require serious planning through joint UCSFCC-SFSU faculty meetings and retreats to 1) identify and prioritize short and long-term pre- doctoral student cancer research training goals and 2) develop a mutually acceptable collaborative pre-doctoral cancer research training program with the guidelines of the R-25E or R-25T or T-32 funding mechanisms. A core element of any final proposal will be the application of recruitment and retention strategies that will result in an increased enrollment of under-represented minorities in Ph.D. programs.