Medicinal Inorganic Chemistry ACS Symposium F-2003

描述（由申请人提供）：本基金用于支付将于2003年9月9日至11日在纽约州纽约举行的美国化学学会（ACS）秋季会议上参加药物无机化学（MIC）研讨会的部分旅费、注册费和当地费用。本次研讨会是由美国化学学会无机化学分会和药物化学分会联合主办的首次此类研讨会。它旨在扩展和支持新发起的同名戈登会议（MIC-GRC），该会议于2002年7月在科尔比-索耶学院开幕，计划于2004年7月在同一地点举行。正如MIC-GRC会议一样，MIC-ACS研讨会的目的是概述该领域的最新技术，从药物设计到开发再到临床试验，介绍医学重要性的含金属系统的最新研究，并促进该领域新的合作研究努力的形成。然而，研讨会的设计具有更高的教学成分，并且比GRC的内容更具包容性。特别是，MIC-GRC会议的目的是召集知名专家进行高级别（正式保密）讨论，而目前MIC-ACS研讨会的主要目标是吸引新的研究人员进入该领域，并向他们提供进行金属基药物制剂研究所需的理解。因此，与MIC-GRC不同，MIC-ACS研讨会将以指导会议为特色，旨在展示将假定的金属基药物从实验室带到初步临床试验的必要条件。本次研讨会要强调的具体主题包括：1)金属自由基在健康和疾病中的作用；2)健康和疾病中的金属蛋白；3)金属蛋白作为药物靶点；4)金属和金属配合物的运输；5)磁共振显像剂；6)金属离子、金属配合物与疟疾；7)放射显像剂；8)钒和铬在健康和疾病中的作用；9)金属离子与核酸的相互作用。这种主题的混合，将通过一系列的研究讲座来涵盖，以补充辅导课，以及通过海报会议。因此，预计目前的MIC-ACS研讨会将提供一个独特的机会，在一个充满机会和NIH使命中心的研究领域进一步发展。

DESCRIPTION (provided by applicant): Funds are requested to defray in part the travel, registration, and local expenses of participants in the Medicinal Inorganic Chemistry (MIC) symposium to be held at the Fall American Chemical Society (ACS) meeting in New York, NY, September 9-11, 2003. This symposium, the first of its kind, is sponsored jointly by the Inorganic Chemistry and the Medicinal Chemistry Divisions of the ACS. It is intended to extend and support the newly initiated set of Gordon Conferences of the same name (MIC-GRC) that were inaugurated at Colby-Sawyer College in July 2002 and which are planned for the same venue in July of 2004. As has been true for the MIC-GRC meetings, the purpose of the MIC-ACS symposium is to outline the state-of-the-art in the field, from drug design to development to clinical trials, present up-to-the-minute research on metal-containing systems of medical importance, and foster the formation of new collaborative research efforts in the field. However, the symposium is designed to have a higher teaching component and be substantially more inclusive than the GRC's. In particular, whereas, the MIC-GRC meetings are designed to bring together established experts for high level (and formally confidential) discussions, a prime goal of the present MIC-ACS symposium is to attract new researchers to the area and provide them with an understanding of what is needed to conduct research on metal-based pharmaceutical agents. Thus, unlike the MIC-GRC, the MIC-ACS symposium will feature a tutorial session designed to show what is necessary to bring a putative metal-based drug substance from the laboratory to the point of initial clinical trials. Specific topics to be emphasized in this symposium include 1) the role of metal-generated radicals in health and disease; 2) metalloproteins in health and disease; 3) metalloproteins as drug targets; 4) transport of metals and metal complexes; 5) magnetic resonance imaging agents; 6) metal ions, metal complexes and malaria; 7) radioimaging agents; 8) vanadium and chromium in health and disease and, 9) metal ion-nucleic acid interactions. This mixture of topics, which will be covered through a series of research lectures designed to complement the tutorial session, as well as through poster sessions. It is thus expected that the present MIC-ACS symposium will afford a unique opportunity to develop further growth in a field of study that is rich in opportunity and central to the NIH mission.