Bruker AVANCE III HD 500 MHz NMR

布鲁克 AVANCE III HD 500 MHz NMR

• 批准号: 9074825
• 负责人: Jonathan L Sessler
• 金额: $ 52.92万
• 依托单位: UNIVERSITY OF TEXAS AT AUSTIN
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-03-15 至 2018-03-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9074825
• 关键词: Address; Biomedical Research; Cell Nucleus; Chemicals; Complex; Data; Data Storage and Retrieval; Development; Disasters; Disease; Enzymes; Funding; Mediating; Methodology; Molecular; NMR Spectroscopy; Nature; Nitrogen; Pathway interactions; Phase; Positioning Attribute; Reagent; Request for Proposals; Research Infrastructure; Research Personnel; Sampling; Structure; Texas; Time; United States National Institutes of Health; Universities; austin; base; catalyst; design; expectation; instrument; instrumentation; receptor

 DESCRIPTION (provided by applicant): This proposal requests the acquisition of a Bruker AVANCE III HD 500 MHz NMR spectrometer with a Prodigy (nitrogen-based) cryoprobe attachment and SampleCASE 24-position sample changer. This instrument is essential to address what is a looming crisis in NMR infrastructure at the University of Texas at Austin (UT Austin) due to both a lack of current capacity and the pending lack of support on the part of Agilent for the existing NMR spectrometers at UT Austin. This new, requested spectrometer with its two key accessories, will enable a number of capabilities that will advance biomedical research on the UT Austin campus. These include: 1) the highest sensitivity for a currently available 500 MHz instrument and one that is 2-3 times better than any existing NMR instrumentation at UT Austin for all nuclei from 15N to 31P. 2) Bruker automatic tuning, making changing nuclei and samples facile, and 3) a sample changer that permits users to submit their samples to a queue with automated sample loading, shimming, parameter optimization, probe tuning and data storage, thus enhancing efficiency. It is not an overstatement that NMR analyses are critical to all biomedical research being carried out at UT Austin that has at least some chemical component. NMR spectroscopy is used to confirm (or refute) that new molecules have been made as per design expectations and to analyze whether a given structure exists in the conformational form originally envisioned. NMR analyses are also critical to the development of new synthetic methodologies and are essential for understanding how a particular reagent or catalyst functions at the molecular level. NMR is also used to probe inter- and intramolecular interactions, thus allowing an understanding how, e.g., synthetic receptors and natural enzymes mediate their function. NMR is also critical to understanding complex biosynthetic pathways and the molecular nature of disease states. The current lack of NMR instrumental capacity is limiting progress on NIH-funded projects and stymieing emerging investigators from obtaining the data they need to compete successfully for NIH support. The requested NMR capabilities to UT Austin will not only address this deficit and the looming disaster associated with Agilent's decision to phase out support for existing spectrometers, it wil allow for an analytical capability that has not hitherto been seen on the UT Austin campus. This proposed acquisition will thus address existing problems, stave off pending ones, and allow for an overall enhancement in the level of NIH-supported biomedical research being carried out our university. The case for this instrument could not be more compelling.

 描述（由申请人提供）：本提案要求购买Bruker AVANCE III HD 500 MHz NMR光谱仪，配有Prodigy（氮基）冷冻探针附件和SampleCASE 24位进样器。该仪器对于解决德克萨斯大学奥斯汀分校（UT Austin）NMR基础设施中迫在眉睫的危机至关重要，这是由于缺乏当前能力以及安捷伦对UT Austin现有NMR光谱仪的支持。这种新的，要求光谱仪与其两个关键配件，将使一系列的能力，将推进生物医学研究在UT奥斯汀校园。其中包括：1）目前可用的500 MHz仪器的最高灵敏度，并且对于从15 N到31 P的所有核，该仪器比UT Austin的任何现有NMR仪器好2-3倍。2)布鲁克自动调谐，使更换原子核和样品变得容易; 3）样品更换器，允许用户将其样品提交到具有自动样品加载、匀场、参数优化、探针调谐和数据存储的队列中，从而提高效率。这不是一个夸张的说法，核磁共振分析是至关重要的所有生物医学研究正在进行的UT奥斯汀，至少有一些化学成分。NMR光谱用于确认（或反驳）新分子已按照设计预期制成，并分析给定结构是否以最初设想的构象形式存在。NMR分析对于开发新的合成方法也至关重要，对于了解特定试剂或催化剂在分子水平上的功能也至关重要。NMR还用于探测分子间和分子内的相互作用，从而允许理解如何，例如，合成受体和天然酶介导它们的功能。NMR对于理解复杂的生物合成途径和疾病状态的分子性质也至关重要。目前缺乏NMR仪器能力限制了NIH资助项目的进展，并阻碍了新兴研究人员获得成功竞争NIH支持所需的数据。UT Austin所要求的NMR能力不仅可以解决这一缺陷以及与安捷伦决定逐步淘汰对现有光谱仪的支持相关的迫在眉睫的灾难，还可以实现UT Austin校园迄今为止尚未看到的分析能力。因此，这项拟议的收购将解决现有的问题，避免悬而未决的问题，并允许在NIH支持的生物医学研究的水平正在进行我们的大学的整体提高。这项文书的理由再引人注目不过了。

项目成果

Sequencing of Sequence-Defined Oligourethanes via Controlled Self-Immolation.

• DOI: 10.1021/jacs.9b12818
• 发表时间: 2020-02-12
• 期刊: Journal of the American Chemical Society
• 影响因子: 15
• 作者: Dahlhauser SD;Escamilla PR;VandeWalle AN;York JT;Rapagnani RM;Shei JS;Glass SA;Coronado JN;Moor SR;Saunders DP;Anslyn EV
• 通讯作者: Anslyn EV

Alternating oligo(o,p-phenylenes) via ruthenium catalyzed diol-diene benzannulation: orthogonality to cross-coupling enables de novo nanographene and PAH construction.

• DOI: 10.1039/c8sc03236j
• 发表时间: 2018-10-28
• 期刊: Chemical science
• 影响因子: 8.4
• 作者: Kasun ZA;Sato H;Nie J;Mori Y;Bender JA;Roberts ST;Krische MJ
• 通讯作者: Krische MJ

Highly fluorinated metal complexes as dual 19F and PARACEST imaging agents.

作为双 19F 和 PARACEST 显像剂的高度氟化金属络合物。

• DOI: 10.1039/c9dt01852b
• 发表时间: 2019
• 期刊: Dalton transactions (Cambridge, England : 2003)
• 作者: Yu,Meng;Bouley,BaileyS;Xie,Da;Que,EmilyL
• 通讯作者: Que,EmilyL

Stereoselective Total Synthesis of (±)-Alstoscholarisine E.

(±)-Alstoscholarisine E 的立体选择性全合成。

• DOI: 10.1021/acs.orglett.9b04093
• 发表时间: 2020
• 期刊: Organic letters
• 影响因子: 5.2
• 作者: Wood,MichaelD;Klosowski,DanielW;Martin,StephenF
• 通讯作者: Martin,StephenF

Determination of Enantiomeric Excess and Diastereomeric Excess via Optical Methods. Application to α-methyl-β-hydroxy-carboxylic acids.

通过光学方法测定对映体过量和非对映体过量。

• DOI: 10.1039/d2qo01444k
• 发表时间: 2023
• 期刊: Organic chemistry frontiers : an international journal of organic chemistry
• 作者: Moor,SarahR;Howard,JamesR;Herrera,BrendenT;McVeigh,MatthewS;Marini,Federico;Keatinge-Clay,AdrianT;Anslyn,EricV
• 通讯作者: Anslyn,EricV