Intl Pediatric Inflammatory Bowel Disease (IBD) Meeting

描述（由申请人提供）： 要求为题为“国际小儿炎症性肠病会议”的科学讲习班提供资金。研讨会由凯斯西储大学和美国克罗恩病和结肠炎基金会主办，将于2003年9月16日至18日举行。讲习班将有大约100名与会者参加，将包括五次科学会议，每次会议由主要研究人员主持，并有6名发言者。该会议是有史以来第一次此类会议，将重点关注全球儿科人群中IBD发病率上升的问题，并解决严重缺乏儿童克罗恩病和溃疡性结肠炎发病机制研究的问题。主要议题将包括儿童免疫系统的发展及其对新生儿和成人免疫力的影响，T细胞在健康和疾病的早期和成人生活中的差异反应性，肠道微生物群及其与IBD的相关性，环境因素对IBD发病机制和表现的影响，以及面对新兴诊断和治疗技术治疗儿科IBD的新趋势。这些都是对IBD具有不可否认的重要性的全新和未探索的领域。研讨会的结果预计将确定儿科IBD缺乏病理生理学研究的原因，并刺激儿科胃肠病学家和IBD研究人员迄今尚未探索的领域的研究。会议的一个主要目标是促进IBD领域以外的科学家与对克罗恩病和溃疡性结肠炎感兴趣的新老研究人员之间的密切互动和科学交流。研讨会的另一个目标是让大量的学员，博士后研究员和初级教师接触新的想法，概念和方法，这些想法，概念和方法将在不久的将来成为儿科IBD的科学关注中心。

DESCRIPTION (provided by applicant): Funding is requested for a scientific workshop entitled "International Pediatric Inflammatory Bowel Disease (IBD) Meeting". The workshop is under the auspices of Case Western Reserve University and the Crohn's & Colitis Foundation of America, and will be held from September 16 through 18, 2003. The workshop will be attended by approximately 100 participants and will include five scientific sessions, each one presided by leading investigators and including 6 speakers. The conference, the very first ever of its kind, will focus on the issue of the raising incidence of IBD in the pediatric population worldwide, and address the serious lack of studies on the pathogenesis of Crohn's disease and ulcerative colitis in children. The major topics will include the development of the immune system in children and its impact on neonatal and adult immunity, the differential reactivity of T-cells in early and adult life in health and disease, the intestinal microbiota and its relevance to IBD, the impact of environmental factors on IBD pathogenesis and manifestations, and new trends in the treatment to pediatric IBD in face of emerging diagnostic and therapeutic technologies. These are completely novel and unexplored areas of undeniable importance to IBD. The outcome of the workshop is expected to define the reasons for the lack of pathophysiology-based research in pediatric IBD and stimulate investigation in areas so far unexplored by pediatric gastroenterologists and IBD investigators. A major goal of the conference is to foster a close interaction and scientific exchange between scientists outside of the field of IBD with established and new investigators interested in Crohn's disease and ulcerative colitis. An additional goal of the workshop is to expose a substantial number of trainees, post-doctoral fellows and junior faculty members to novel ideas, concepts and methodologies that will become the center of scientific attention in pediatric IBD in the immediate future.