FASEB Research Conf: Glucose Transporter Biology

描述(由申请人提供)： 这是一份申请申请，请求部分支持由美国实验生物学学会联合会(FASE B)主办的夏季研究会议“葡萄糖转运蛋白生物学”。这次会议定于2003年8月9日至8月14日在科罗拉多州的斯诺马斯村举行。这将是第六次专门研究葡萄糖运输和代谢的细胞、分子和生理调节的双年度国际会议。本次会议的目的是关注对我们的理解有直接影响的新颖、尖端的方法和发现：1)维持正常血糖稳态所必需的复杂的调控过程；2)导致这一过程调节失调导致胰岛素抵抗和糖尿病的病理条件。此外，这次会议将提供一个场所，鼓励和促进这一疾病研究关键领域的新的年轻研究人员。本次会议的与会者总数将限制为150人，他们来自具有临床和/或基础科学背景的个人，根据他们的专业知识和兴趣进行挑选。将有八个主要的科学会议，包括4-5次受邀演讲，每次约30分钟(20分钟+10分钟讨论)，然后15-30分钟时间将提出选定的摘要和/或最新数据。在每一次会议结束时，还将有20分钟的时间进行总体一般性讨论。还将在整个会议期间张贴海报，并将在两个下午的会议上组织具体的海报展示。选定海报摘要的口头介绍和海报会议本身将为初级参与者提供与该领域专家直接互动和讨论其数据的机会。将讨论的八个具体主题包括：1)葡萄糖转运蛋白基因家族，2)GLUT表达调控，3)葡萄糖转运蛋白生理学/病理生理学，4)葡萄糖利用和胰岛素敏感性的生理学，5)运输囊泡运输，6)GLUT4运输，7)GLUT信号转导，8)脂筏和小窝。将界定和讨论每一届会议中存在的共识、争议和不确定性领域。重要的是，选择这些领域是为了为对葡萄糖转运蛋白生物学/生物化学细胞生物学感兴趣的基础和临床科学家提供一个独特的机会，让他们在密切相关但截然不同的研究领域相互交流，并与其他科学家互动。与以往的情况一样，本次会议的互动环境将促进与会者之间的合作研究努力，并将确定未来的关键目标，以帮助我们理解葡萄糖转运蛋白调节和负责维持葡萄糖动态平衡的机制。

DESCRIPTION (provided by applicant): This is an application requesting partial support for a summer research conference entitled "GLUCOSE TRANSPORTER BIOLOGY" sponsored by the Federation of American Societies for Experimental Biology (FASEB). This conference has been scheduled to take place from August 9 to August 14, 2003 in Snowmass Village, Colorado. This will be the sixth bi-annual international meeting specifically devoted to the cellular, molecular and physiological regulation of glucose transport and metabolism. The aim of this conference is to focus on novel, cutting-edge approaches and findings that have a direct impact on our understanding of 1) the complex regulatory processes that are necessary to maintain normal glucose homeostasis and 2) the pathological conditions that result in dysregulation of this process resulting in insulin resistance and diabetes. In addition, this conference will provide a venue to encourage and promote new young investigators in this critical area of disease research. In total, this conference will be limited to 150 participants from individuals with clinical and/or basic science backgrounds, selected on the basis of their expertise and interests. There will be eight major scientific sessions consisting of 4-5 invited talks, approximately 30 min each (20 min + 10 min discussion) followed by a 15-30 min period where selected abstracts and/or late breaking data will be presented. At the end of each session, there will also be a 20 min period for an overall general discussion. Posters will also be displayed throughout the duration of the meeting and specific poster presentations will be organized in two afternoon sessions. The oral presentation of selected poster abstracts and the poster sessions themselves will provide opportunities for junior participants to directly interact with and discuss their data with experts in the field. The eight specific topics that will be discussed include: 1) Glucose transporter gene family, 2) Regulation of GLUT expression, 3) Glucose transporter physiology/pathophysiology, 4) Physiology of glucose utilization and insulin-sensitivity, 5) Transport vesicle trafficking, 6) GLUT4 trafficking, 7) Signaling to GLUTs, and 8) Lipid rafts and caveolae. The areas of agreement, controversy, and uncertainty within each of these sessions will be defined and discussed. Importantly, these areas have been selected to provide a unique opportunity for basic and clinical scientists interested in glucose transporter biology/biochemistry cell biology to interact with each other and with other scientists in closely related but distinct research fields. As has previously been the case, the interactive environment at this conference will stimulate collaborative research efforts among the conferees and will identify the future critical goals for our understanding of glucose transporter regulation and the mechanisms responsible for the maintenance of glucose homeostasis.