GRC on Second Messengers & Protein Phosphorylation

描述（由申请人提供）：我们正在请求部分支持戈登研究会议（GRC）的运作第二信使和蛋白质磷酸化，这是自70年代初以来每年举行一次。 多年来，这个GRC一直是导致多项诺贝尔奖的研究首次颁发的场所。 会议每年在新罕布什尔州梅里登的金博尔联合学院举行，该学院提供了一个熟悉的残疾人无障碍场所，以促进与会者之间的开放互动。 2003年的GRC迭代将于6月8日星期日晚上开始，并于6月12日星期四晚上结束。 会议的重点是调节细胞生长，分化，存活和代谢的信号转导机制。 充分了解这些信号传导机制在科学和临床上都很重要，因为它们的失败在影响全球数百万人的当代健康问题中起着直接作用，如糖尿病，肥胖，衰老，癌症，心血管疾病，神经退行性疾病和发育障碍。 鼓励演讲者整合生物化学，结构，细胞生物学和基因组学方法，这些方法提供了对与疾病相关的信号传导机制的分子方面的全面理解。 全体发言人已被选定为会议奠定基础，并挑战与会者从新的角度思考信号转导。 会议将包括8场会议，每场会议由一名讨论负责人和四名发言人组成，发言人从最近作出重要贡献的调查人员中选出。 至少20%的发言者是妇女或少数群体成员。 每个环节的演讲者将开发信号转导重要范例的结构和功能，并将这些系统与疾病机制和潜在的治疗策略联系起来。 联合主席将从申请者中选出135名参与者，包括来自工业界和学术界的代表、资深科学家、博士后研究员和研究生。 将作出特别努力，通过直接邮寄方案招募少数族裔与会者。 鼓励参加者每天下午展示关于新的和有趣的结果的海报。 重要的是，这次会议为年轻的研究人员提供了一个论坛，让他们看到基础科学探究与科学方法应用于设计人类疾病有效干预措施之间的联系。 为了强调这一目标，将挑选四个与会议主题相辅相成的海报介绍，在主要会议期间作简短的口头介绍。

DESCRIPTION (provided by applicant): We are requesting partial support for operation of the Gordon Research Conference (GRC) on Second Messengers and Protein Phosphorylation, which has been held annually since the early 70's. Over the years this GRC has been the venue where research leading to several Nobel Prizes was first presented. The meeting is held annually at Kimball Union Academy in Meriden, New Hampshire, which provides a familiar and handicapped-accessible venue to promote open interaction among participants. The 2003 iteration of this GRC will begin on Sunday night June 8 and conclude on Thursday evening June 12. The conference focuses on signal transduction mechanisms that regulate cell growth, differentiation, survival and metabolism. A full understanding of these signaling mechanisms is scientifically and clinically important because their failure plays a direct role in contemporary health problems that affect millions of people worldwide, such as diabetes, obesity, aging, cancer, cardiovascular disease, neurodegeneration, and developmental disorders. The speakers are encouraged to integrate biochemical, structural, cell biological and genomic approaches that provide a comprehensive understanding of the molecular aspects of signaling mechanisms as they relate to disease. The plenary speaker has been selected to set the stage for the conference and to challenge the participants to think about signal transduction from novel perspectives. The conference will consist of 8 sessions, each with a discussion leader and four speakers, selected from investigators who have made important recent contributions. At least 20% of the speakers are women or members of minority groups. Speakers in each session will develop the structure and function of important paradigms in signal transduction and relate these systems to disease mechanisms and potential treatment strategies. The co-chairs will select 135 participants from applicants, including representatives from industry and academia, senior scientists, postdoctoral fellows and graduate students. A special effort will be made to recruit minority participants by a direct mailing program. Participants will be encouraged to present posters on new and interesting results each afternoon. Importantly, the conference provides a forum for young investigators to see the connection between fundamental scientific inquiry and the application of scientific methods to the design of efficacious interventions for human disease. To emphasize this goal, four poster presentations that complement the themes of the meeting will be selected for brief oral presentation during the main sessions.